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Molecular Biology of Chronic Diseases laboratory

microRNA; RNA; obesity; diabetes; cancer; gene expression

Dr. Ari Meerson

+972-4-6953530
+972-4-6944980
Contact Dr. Ari Meerson

We study the molecular basis of chronic diseases, focusing on the function of microRNAs, short RNA molecules that regulate gene expression and are involved in a variety of biological pathways. MicroRNAs may act as a functional link between different chronic diseases, and hold promise as potential biomarkers and therapeutic targets. Specifically, we are interested in:

1.    MicroRNAs as a mechanistic link between metabolic disease and cancer

2.    Discovery of microRNA-based biomarkers in body fluids


 

CV

Education

Ph.D. 2009, Department of Biological Chemistry Hebrew University, Jerusalem, Israel.
M.Sc. 2004, Department of Molecular Cell Biology, Feinberg Graduate School of the Weizmann Institute of Science, Rehovot, Israel.

Academic and research positions

2013-present, Head of Molecular Biology of Chronic Diseases laboratory, Migal
2017-present, Tel Chai Academic College, Kiryat Shmona. Developmental Genetics course (plan) 
2015-2018 University of Copenhagen, Denmark. Visiting Researcher with Prof. Thorkil Ploug
2009-2013, Postdoctoral Fellow at NIH/NIDDK (Phoenix), Arizona, USA

Honors and awards

2015-2017, Type 2 diabetes research grant, D-Cure/CSO-MOH
2013-2015, Gesher Award, Israel Cancer Research Fund/MOST
2015, Visiting Professorship, Danish Diabetes Academy (Novo Nordisk Foundation)
2014, Travel Award, The Daniel Turnberg UK/Middle East Travel Fellowship Scheme
2013, Travel Award, Copenhagen Bioscience Conferences (Novo Nordisk Foundation)
2011, NIDDK Nancy Nossal Fellowship Award (intramural grant competition)

Selected Publications

Obesity impacts the regulation of miR-10b and its targets in primary breast tumors.

BMC Cancer 2019 Volume 19 Issue 86 Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW. Read online

Sex differences in plasma microRNA biomarkers of early and complicated diabetes mellitus in Israeli Arab and Jewish patients.

Non-coding RNA 2019 Volume 5 Issue 2 Pages 32 Meerson A, Najjar A, Saad E, Sbeit W, Barhoum M, Assy N.
Read online

Leptin and insulin up-regulate miR-4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells

BMC Cancer 2016 Meerson A, Yehuda H Read online

Human adipose microRNA-221 is up-regulated in obesity and affects fat metabolism downstream of leptin and TNFa

Diabetologia 2013 Volume 56 Issue 9 Pages 1971-9 Meerson A, Traurig M, Ossowski V, Fleming JM, Mullins M, Baier LJ. Read online

MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase

Immunity 2009 Volume 31 Issue 6 Pages 965-973 I. Shaked; A. Meerson; Y. Wolf; R. Avni; D. Greenberg; A. Gilboa-Geffen; H. Soreq Read online

Students

Post-graduate and post-doctoral research training

Researchers

Laboratories and research projects

Business

Business opportunities and technology transfer