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Medical and Diagnostic Instruments Development

Dr. Doron Goldberg

Contact Dr. Doron Goldberg

Research topics:
1. Developing an accurate self-referenced Optical Rotation (OR) polarimeter for High-Pressure Liquid Chromatography (HPLC) applications
OR polarimeters are used to measure the rotation of plane-polarized light by optically active substances. Such measurements are especially important in the pharmaceutical industry where they are used in the chromatographic separation of optical isomers. However, current commercial OR polarimeters for HPLC are severely limited by their susceptibility to various sources of polarization noise. Our Self-Referenced OR Detector (SROD) solves this problem by employing an efficient signal amplification mechanism, and generating a semi-continuous reference signal using only a single laser beam. The reference signal is used to distinguish between polarization artifacts (pseudo-rotations) and the true OR signal – thereby allowing the measurement of small optical rotations (~20e-6°) with resolution and reliability previously unattainable.

2. Developing an optical glucose sensor and implanted spectroscopy for diabetics
The use of an artificial pancreas to treat diabetics is still an unsolved problem. The main obstacle blocking its implementation is the lack of a sufficiently reliable glucose sensor. We believe that better glucose monitoring must rely on chronically implanted optical sensors. To this end, we explore the possibility to miniaturize our polarimeter down to a size of a pacemaker and also to conduct long-term spectroscopic measurements in the interstitial fluid by using an implanted measurement cell equipped with a tiny pump.



Ph.D. Department of Biochemistry, the Faculty of Natural Sciences at The Hebrew University, Jerusalem.
M.Sc. (Summa cum laude), Department of Biochemistry, the Faculty of Natural Sciences at The Hebrew University, Jerusalem.

Academic and research experience
Researcher, MIGAL Galilee Research Institute,
Staff member and senior lecturer at Tel-Hai Academic College

Selected Publications

Compact, high-resolution, self-referenced, optical activity polarimeter for high-pressure liquid chromatography systems

Appl. Optץ 2014 Volume 53 Pages 577-587 D. Goldberg, and Z. Weissman

Heterodyne Polarimeter with a Background Subtraction System

US 2009 D. Goldberg, and Z. Weissman


Post-graduate and post-doctoral research training


Laboratories and research projects


Business opportunities and technology transfer