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Oxidative Stress and human diseases

Prof. Jacob Vaya

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The Oxidative Stress (OS) and Human Diseases group is focused on research related to the association between the two. We engaged in the following subjects:

The design and use of multifunctional synthetic markers for the characterization of OS and application to human diseases. Markers are constructed from several subunits representing proteins, unsaturated fatty acids, sterols and DNA connected together covalently, and alterations in these markers due to OS are analyzed by LC/MS. These markers can be used ex vivo, by incubating them with body fluids (blood, urine, saliva), tissues (brain, plaques) or cells, or in vivo by microdialysis technique, (Vaya, Biochimie, 2013).

Identification of VOCs specific for PD in the blood of PD Patients
Each disease may characterize by specific metabolic pathways which can result with the formation of specific volatile compounds (VOCs) in the blood. Detection of these volatile agents and analyses them in the blood of de-novo patients by GC-MS using solid phase micro extraction (SPME) technique may allow early detection and metabolic characterization of the disease. These samples are pre-concentrated on SPME fibers from blood and injects into the GC-MS. Based on the type of identified biomarkers an investigation is followed to find links between the identified biomarker to its biochemical pathways origin. Same technique could be utilized for early identification of other human diseases.
Because human atherosclerotic plaques are in constant contact with blood, we are investigating the impact of the plaque components on blood elements and vice versa, to identify markers which may provide information on plaque vulnerability (Cohen et al., Journal of Lipids, 2012; Vaya et al., Current Opinion in Lipidology, 2013).

In addition, the impact of interactions between small molecules and proteins on both is being investigated (Atrahimovich et al., Bioorganic & Medicinal Chemistry, 2013), and we are producing modified proteins (antibodies) with an immune-silencing response while preserving their native binding site (Gefen et al., International Immunopharmacology, 2013).


 

CV

Education
Ph.D. 1978, Chemistry, Weizmann Inst. Rehovot, Israel.
M.Sc. 1973 Chemistry, Hebrew Uni. Jerusalem, Israel.

Academic and research experience
2008 - Professor, Tel Hai Academic College
2003 - Associate Professor, Tel Hai Academic College
1992 - Faculty member in Tel Hai Academic College, and head of Oxidative Stress and human diseases laboratory

Other Activity and Service
2012- President of the Israel Society for Oxygen and Free Radicals Research
2012- Member of the Council for Higher Education

Selected Publications

Selective inhibition of monoamine oxidase A or B reduces striatal oxidative stress in rats with partial depletion of the nigro-striatal dopaminergic pathway

Neuropharmacology 2013 Volume 65 Pages 48-57 Y. Aluf; J. Vaya; S. Khatib; Y. Loboda; J. P. M. Finberg Read online

The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study

Bioorganic and Medicinal Chemistry 2013 Volume 21 Issue 11 Pages 3348-3355 D. Atrahimovich; J. Vaya; S. Khatib Read online

Exogenous markers for the characterization of human diseases associated with oxidative stress

Biochimie 2013 Volume 95 Issue 3 Pages 578-584 J. Vaya Read online

Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion

Free Radical Biology and Medicine 2011 Volume 51 Issue 1 Pages 234-242 H. Tavori; M. Aviram; S. Khatib; R. Musa; D. Mannheim; R. Karmeli; J. Vaya Read online

Mannosamine-biotin as a novel masking agent for coating IgG for immune response silencing and augmentation of antibody-antigen interaction

Vaccine 2009 Volume 27 Issue 49 Pages 6869-6876 J. Vaya; E. Aizenshtein; S. Khatib; T. Gefen; M. Fassler; R. Musa; S. Krispel; J. Pitcovski Read online

Students

Post-graduate and post-doctoral research training

Researchers

Laboratories and research projects

Business

Business opportunities and technology transfer