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Laboratory of vascular signaling research

EDHF; CYP-epoxygenase; vascular dilation; PON1; PUFA

Dr. Andrea Szuchman-Sapir

97246953521
Contact Dr. Andrea Szuchman-Sapir

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium–derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated


 

CV

Education
Ph.D. 2005, Technion Faculty of Medicine, Haifa, Israel.
M.Sc. 2000, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Academic and research positions

2017- Head of the Laboratory of vascular signaling research, Migal-Galilee Research Institute 2017- Head of the IRB committee at the Tel-Hai College, Israel                            

Since 2011: Faculty member, Tel-Hai academic college, Israel

2009-2016 Scientist at the Human Health & Nutrition Sciences laboratory, Migal-Galilee Research Institute 
2009-2013: Lecturer, Tel-Hai Academic College, Israel
2007-2009: Post-Doctoral at the Vascular Biology Group, ANZAC Research Institute, Concord Hospital, in collaboration with the Heart Research Institute, Sydney, Australia.

Honors and awards

2018-2020: Arterial dilating activity of an EPA metabolite, a novel endothelial- derived hyperpolarizing factor (EDHF), as an anti- hypertensive drug candidate. Israel Innovation Authority. In collaboration with Prof. Shaul Atar, Galilee Medical Center, Nahariya

2016-2018: PON1 regulate blood pressure via EDHF. BSF- start-up grant. In collaboration with Prof. Gutterman David, Medical College of Wisconsin, Milwaukee, USA.

2015-2018: The regulation of 5,6-DHTL, a new endothelial-derived hyperpolarizing factor, by paraoxonase 1 in the modulation of vascular tone. ISF- Israel Science Foundation research fellowship.

2012-2015: Novel pathway for blood pressure regulation involving paraoxonase 1 and epoxygenase arachidonic acid metabolites. ISF - Israel Science Foundation research fellowship.

2012-2013: The Israeli Society for Research, Prevention and Treatment of Atherosclerosis.

Other Activity and Service

Since 2016: Senior lecturer at the Tel-Hai college, Israel

Since 2017: Chairman of the Tel-Hai Institutional Review Board (IRB) for human subject research.

Since 2013: Treasurer of the Israeli Society for Oxygen and Free Radical Research.
Since 2013: Member of the Tel-Hai Institutional Review Board for human subject research.

Selected Publications

Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Volume 1864 Issue 3 Pages 386-393 Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A. Read online

In-vivo oxidized albumin– a pro-inflammatory agent in hypoalbuminemia.

PLoS One 2017 Volume 24 Pages 1-14 Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B. Read online

5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.

FRBM 2017 Volume 103 Pages 87–94 Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A. Read online

5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1

BBA Molecular and Cell Biology of Lipids 2015 Volume 1851 Pages 1118-1122 Eryanni S, Khatib S, Levi-Rosenzvig R, Tamir S, Szuchman-Sapir A Read online

Human atherosclerotic plaque lipid extract impairs the antioxidant defense capacity of monocytes

Biochemical and Biophysical Research Communications 2012 Volume 423 Issue 4 Pages 884-888 A. Szuchman-Sapir; M. Etzman; S. Tamir Read online

Human atherosclerotic plaque lipid extract promotes expression of proinflammatory factors in human monocytes and macrophage-like cells

Atherosclerosis 2011 Volume 218 Issue 2 Pages 339-343 H. Yehuda; A. Szuchman-Sapir; S. Khatib; R. Musa; S. Tamir Read online

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