Research Groups | The Laboratory for Molecular Genetics and Pharmacogenetics | Sigal Korem CV

Place of birth:Ramat Gan , Israel.
Address:Mitzpeh Harashim , 24954, Israel. Tel: 04-7802031.
E-mail: s_ korem@hotmail.com
Maritial status: Married ,+ 3 children.

Education

• 1974-1980 Ohel-Shem High School , Ramat-Gan , Israel.
• 1984-1987 B.Sc. student in Biology, Faculty of Life Sciences ,Tel-Aviv University, Israel.
• 1987-1989 M.Sc. student in Microbiology, Faculty of Life Sciences, Tel-Aviv, University, Israel. Thesis topic: “The effect of naturally occurring antibodies on the immune system and implication on tumor progression induced by polyoma virus” under the supervision of Prof. I.P.Witz and Dr. N.I. Smorodinsky.
• 1987-1989 Biology  teacher studies, Dept.  of Science Education, School of Education, Tel-Aviv University.
  1996-2001 Ph.D. student in Life Sciences,  Faculty of Medicine,
  Thesis topics “The expression and regulation of matrix metalloproteinases in malignant and benign human thyroid cells “ under the supervision of Prof. Z. Kraiem.

Academic degrees

• 1987 B.Sc. degree in Biology , Faculty of Life Sciences, Tel-Aviv University,  Israel.
• 1989 M.Sc. degree in Microbiology, Faculty of Life Sciences, Tel-Aviv University, Israel.
• 1989 Biology teacher diploma , School of Education, Tel- Aviv University.
• 2001 Ph.D degree in Life Sciences, Faculty of Medicine, Technion, Hifa.

Career

• 1983-1986  Army service.
• 1987-1998  Biology teacher, Class Tutor and member of School Board of Directors, Ort-Maalot High School , Israel.
• 2000 Biology teacher at the Open University and in high school.
• 2001 Post doc position at Migal – human genetic departement.

Awards

• 1999 Chowers Prize in Endocrine Recearch, Israel Endocrine Society.
• 2000 Grant from the Society of Cancer Detection and Prevention. Symposium in

Publications

Articles

• ahalon L., Korem S.,Gonen B., Puri J., Smorodinsky N., Witz I.P. Antibody – mediated regulation of tumor growth. Annals New York Academy of Sciences, 1992.
• Korem S., Resnick M., Kraiem Z.Similar and divergent patterns in the regulation of matrix metalloproteinases-1 (MMP-1) and tissue inhibitor of MMP-1 gene expression in benign and malignant human thyroid cells. Journal of Clinical Endocrinology and  Metabolism, 84:829-834, 1999.
• Kraiem Z., Korem S. Matrix metalloproteinases and  the thyroid. Thyroid 10:1061-1069, 2000.
• Korem S., Kraiem E., Shiloni O., Sadeh O., Resnick M.B. Increased expression of matrix metalloproteinase-2 (MMP-2) is characteristic of papillary carcinoma. Israel Journal of the medicine association, 4:247-251, 2001.

Abstracts

• Korem S., Resnick M.B., Kraiem Z.
  TSH acting via protein kinase A, inhibits protein kinase C- and tyrosine kinase C- induced matrix metalloproteinase-2 gene expression in human thyroid carcinoma cells.
  Journal of Endocrinological Investigation, 21, Suppl.4:6.1998
• Korem S., Resnick M.B., Kraiem Z.
  TSH acting via protein kinase A, inhibits protein kinase C- and tyrosine kinase C- induced matrix metalloproteinase-2 gene expression in human thyroid carcinoma cells.
  Proceeding of the 71 Annual Meeting of the America Thyroid Association, Portland.
• Korem S., Resnick M.B., Kraiem Z.
  Similar and divergent patterns in the regulation of matrix metalloproteinase-1 (MMP-1) and tissue inhibitors of MMP-1 gene expression in benign and malignant human thyroid cells.
  (Chowers Prize in Endocrinology Research ,Israel Endocrine Society).
  Proceeding of the Annual Meering of the Israel Endocrine Society , Tel-Aviv, 1999.
• Korem S., Resnick M.B., Kraiem Z.
  Similar and divergent patterns in the regulation of matrix metalloproteinase-1 (MMP-1) and tissue inhibitors of matrix metalloproteinase-1 ( TIMP-1)gene expression in benign and malignant human thyroid cells.
  Proceeding of the 72 Annual Meeting of the America Thyroid Association, Portland.
• Korem S., Resnick M.B., Kraiem Z.
  Similar and divergent patterns in the regulation of matrix metalloproteinase-1 (MMP-1) and tissue inhibitors of matrix metalloproteinase-1 ( TIMP-1) gene expression in benign and malignant human thyroid cells. Proceeding of the 6th International Congress on Hormone and Cancer, Jerusalem 1999.
• Goldman S., Gonen Y,. Korem S,. Kraiem Z.
  Fertilization competence in human is associated with high sperm secretion of 72 kD matrix metalloproteinase ( MMP-2) relative to a much lower 92 kd (MMP-9) . Proceeding of the In Vitro Fertilization Meeting , Sydney, 1999.
• Korem S., Resnick M.B., Kraiem Z.
  The expression and regulation of matrix metalloproteinases and their inhibitors in malignant and benign human thyroid cells. Proceeding of the 5th International Symposium on Impact of Biotechnology on Cancer, Geneva, 2000.
• Korem S,. Kraiem Z,. Shiloni E,. Sadeh O., Resnick M.B.
  Increased expression of matrix metalloproteinase –2  ( MMP-2) is characteristic of papillary carcinoma but not correlate with lymph node metastasis. Proceeding of the Annual Meering of the Israel Endocrine Society , Tel-Aviv, 2000.