Dr. Doron Goldberg

Dr. Doron Goldberg
Research Group Leader
Medical and Diagnostic Instruments Development

Research Topics:
1. Developing an accurate self-referenced Optical Rotation (OR) polarimeter for High-Pressure Liquid Chromatography (HPLC) applications
OR polarimeters are used to measure the rotation of plane-polarized light by optically active substances. Such measurements are especially important in the pharmaceutical industry where they are used in the chromatographic separation of optical isomers. However, current commercial OR polarimeters for HPLC are severely limited by their susceptibility to various sources of polarization noise. Our Self-Referenced OR Detector (SROD) solves this problem by employing an efficient signal amplification mechanism, and generating a semi-continuous reference signal using only a single laser beam. The reference signal is used to distinguish between polarization artifacts (pseudo-rotations) and the true OR signal – thereby allowing the measurement of small optical rotations (~20e-6°) with resolution and reliability previously unattainable.

2. Developing an optical glucose sensor and implanted spectroscopy for diabetics
The use of an artificial pancreas to treat diabetics is still an unsolved problem. The main obstacle blocking its implementation is the lack of a sufficiently reliable glucose sensor. We believe that better glucose monitoring must rely on chronically implanted optical sensors. To this end, we explore the possibility to miniaturize our polarimeter down to a size of a pacemaker and also to conduct long-term spectroscopic measurements in the interstitial fluid by using an implanted measurement cell equipped with a tiny pump.


Ph.D. Department of Biochemistry, the Faculty of Natural Sciences at The Hebrew University, Jerusalem.
M.Sc. (Summa cum laude), Department of Biochemistry, the Faculty of Natural Sciences at The Hebrew University, Jerusalem.

Academic and research experience
Researcher, MIGAL Galilee Research Institute,
Staff member and senior lecturer at Tel-Hai Academic College

Scientific Publications

Optimized polypeptide for a subunit vaccine against avian reovirus.

Goldenberg D, Lublin A, Rosenbluth E, Heller E.D, Pitcovski J.
Vaccine 2016 Volume 34 Pages 3178-3183

Compact, high-resolution, self-referenced, optical activity polarimeter for high-pressure liquid chromatography systems

D. Goldberg, and Z. Weissman
Appl. Opt? 2014 Volume 53 Pages 577-587

cDNA cloning of blue gourami (Trichogaster trichopterus) prolactin and its expression during the gonadal cycles of males and females

G. Degani; S. Yom-Din; D. Goldberg; K. Jackson
Journal of Endocrinological Investigation 2010 Volume 33 Issue 1 Pages 7-12

Molecular variation in triturus vittatus vittatus (Urodela) from breeding sites near the southern extremity of its distribution revealed by DNA sequencing of mitochondrial cytochrome b gene and control region

O. Pearlson; L. Blaustein; S. Snir; D. Goldberg; G. Degani
Current Herpetology 2010 Volume 29 Issue 1 Pages 21-???

Heterodyne Polarimeter with a Background Subtraction System

D. Goldberg, and Z. Weissman
US 2009

cDNA cloning and mRNA expression of growth hormone in Belontiidae (Anabantoidei suborder)

G. Degani; K. Jackson; S. Yom-Din; D. Goldberg
Israel Journal of Aquaculture 2006 Volume 58 Pages 124-136

Cloning of FSHβ, LHβ, and glycoprotein α subunits from the Russian Sturgeon (Acipenser gueldenstaedtii), β-subunit mRNA expression, gonad development, and steroid levels in immature fish

A. Hurvitz; G. Degani; D. Goldberg; S. Y. Din; K. Jackson; B. Levavi-Sivan
General and Comparative Endocrinology 2005 Volume 140 Issue 1 Pages 61-73

Growth hormone of Trichogaster trichopterus: cDNA cloning, sequencing and analysis of mRNA expression during oogenesis

D. Goldberg; K. Jackson; S. Yom-Din; G. Degani
Journal of Aquaculture in the Tropics 2004 Volume 19 Pages 215-229

betaFSH, betaLH and growth hormone gene expression in blue gourami (Trichogaster trichopterus, Pallas 1770) during spermatogenesis and male sexual behavior

G. Degani; K. Jackson; D. Goldberg; R. Sarfati; R. R. Avtalion
Zoological science 2003 Volume 20 Issue 6 Pages 737-743

Cloning of European eel (Anguilla anguilla) FSH-beta subunit, and expression of FSH-beta and LH-beta in males and females after sex determination

G. Degani; D. Goldberg; I. Tzchori; A. Hurvitz; S. Yom Din; K. Jackson
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 2003 Volume 136 Issue 2 Pages 283-293

FSH, LH and growth hormone gene expiration in blue gourami (Trichogaster trichopterus, Pallas, 1770) during spermatogenesis and male sexual behavior

G. Degani; K. Jackson; D. Goldberg; R. Sarfati; R. Avtalion
Zoological Science 2003 Volume 20 Pages 737-743

Growth differences and growth hormone expression in male and female European eels [Anguilla anguilla (L.)]

G. Degani; I. Tzchori; S. Yom-Din; D. Goldberg; K. Jackson
General and Comparative Endocrinology 2003 Volume 134 Issue 1 Pages 88-93

Application of RAPD to genetic variations in eels growing at different rates

K. Jackson; D.Goldberg; Y. Yehuda; G. Degani
Journal of Aquaculture in the Tropics 2002 Volume 17 Pages 241-249

Manganese-containing superoxide dismutase from the white-rot fungus Phanerochaete chrysosporium: Its function, expression and gene structure

P. A. Belinky; D. Goldberg; B. Krinfeld; M. Burger; N. Rothschild; U. Cogan; C. G. Dosoretz
Enzyme and Microbial Technology 2002 Volume 31 Issue 6 Pages 754-764

Application of RAPD in study of genetic variations in Cichlidae in Israel

G. Degani; K. Jackson; D. Goldberg; Y. Yehuda
Journal of Aquaculture in the Tropics 2000 Pages 219-277

Molecular DNA variation in koi (Cyprinus carpio) of various color patterns

K. Jackson; D. Goldberg; Y. Yehuda; G. Degani
Israeli Journal of Aquaculture - Bamidgeh 2000 Volume 52 Issue 4 Pages 151-158

Morchella conica exhibiting a long fruiting season

M. Goldway; R. Amir; D. Goldberg; Y. Hadar; D. Levanon
Mycological Research 2000 Volume 104 Issue 8 Pages 1000-1004

Blue gourami (Trichogaster trichopterus) gonadotropic β subunits (I and II) cDNA sequences and expression during oogenesis

K. Jackson; D. Goldberg; M. Ofir; M. Abraham; G. Degani
Journal of Molecular Endocrinology 1999 Volume 23 Issue 2 Pages 177-187

Application of RPAD in study variations between African and American Cichlidae

D. Goldberg; K. Jackson; Y. Yehuda; G. Degani
Indian Journal of Fisheries 1999 Volume 46 Pages 307-312

Coding region of segment a sequence of a very virulent isolate of IBDV-comparison with isolates from different countries and virulence

J. Pitcovski; D. Goldberg; B. Z. Levi; D. Di-Castro; A. Azriel; S. Krispel; T. Maray; Y. Shaaltiel
Avian Diseases 1998 Volume 42 Issue 3 Pages 497-506

Progesterone receptor detection in paraffin sections of human breast cancers by an immunoperoxidase technique incorporating microwave heating

D. E. Goldberg; J. Stuart; F. C. Koerner
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994 Volume 7 Issue 3 Pages 401-406

A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae

D. Goldberg; I. Marbach; E. Gross; A. Levitzki; G. Simchen
European Journal of Biochemistry 1993 Volume 213 Issue 1 Pages 195-204

Erratum: Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras (Nature 360, 762-765 (1992))

E. Gross; D. Goldberg; A. Levitzki
Nature 1993 Volume 361 Issue 6409 Pages 278

Is the neuronal voltage-sensitive calcium channel of human brain, human pancreatic β cells and rat brain much larger than predicted by its cDNA sequence? [1]

A. Osherov; D. Goldberg; D. Atlas
Neuroscience Letters 1992 Volume 147 Issue 2 Pages 233-235

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

E. Gross; D. Goldberg; A. Levitzki
Nature 1992 Volume 360 Issue 6406 Pages 762-765