Plant-based Cancer Drug Discovery

Prof. Jamal Mahajna

The Shaggy Inc Cap medicinal mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) substances interfere with H2o2 induction of the NF-κB pathway through inhibition of IκBα phosphorylation in MCF7 breast cancer cells

M. D. Asatiani; S. P. Wasser; E. Nevo; N. Ruimi; J. Mahajna; A. Z. Reznick
International Journal of Medicinal Mushrooms 2011 Volume 13 Issue 1 Pages 19-25
2011

NF-κB activation by peroxynitrite through IκBα-dependent phosphorylation versus nitration in colon cancer cells

E. Gochman; J. Mahajna; A. Z. Reznick
Anticancer Research 2011 Volume 31 Issue 5 Pages 1607-1617
2011

Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity

H. Khamaisie; S. Sussan; M. Tal; Y. Najajreh; M. Ruthardt; J. Mahajna
Anticancer Research 2011 Volume 31 Issue 1 Pages 177-183
2011

A dual mechanism of NF-?B activation by peroxynitrite through p38 MAP kinase dependent I?B? phosphorylation, versus I?B? nitration in colon cancer cells.

Gochman, E., Mahajna, J. & Reznick, A.
Anticancer Research 2011 Volume 31 Pages 1607-1617
2011

Targeting the oligomerization of BCR/ABL by membrane permeable competitive peptides inhibits the proliferation of Philadelphia Chromosome positive leukemic cells

A. A. Mian; M. Schüll; C. Oancea; Y. Najajreh; J. Mahajna; A. Goldblum; O. G. Ottmann; T. Beissert; M. Ruthardt
Open Hematology Journal 2011 Volume 5 Issue 1 Pages 21-27
2011

Crude extracts from the Culinary-medicinal Mushroom Coprinus comatus as Natural Anti-androgenic Modulators. Integrative Cancer Therapies

Dotan, N., Wasser, S.P. & Mahajna, J.
Integrative Cancer Therapies 2011 Volume 10 Pages 148-159.
2011

The culinary-medicinal mushroom Coprinus comatus as a natural antiandrogenic modulator

N. Dotan; S. P. Wasser; J. Mahajna
Integrative Cancer Therapies 2011 Volume 10 Issue 2 Pages 148-159
2011

Daedalea gibbosasubstances inhibit LPS-induced expression of iNOS by suppression of NF-γB and MAPK activities in RAW 264.7 macrophage cells

N. Ruimi; H. Rwashdeh; S. Wasser; B. Konkimalla; T. Efferth; M. Bprgatti; R. Gambari; J. Mahajna
International Journal of Molecular Medicine 2010 Volume 25 Issue 3 Pages 421-432
2010

Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms

N. Ruimi; R. D. Petrova; R. Agbaria; S. Sussan; S. P. Wasser; A. Z. Reznick; J. Mahajna
Molecular Biology Reports 2010 Volume 37 Issue 8 Pages 3801-3812
2010

Pharmacological values of medicinal mushrooms for prostate cancer therapy: The case of Ganoderma lucidum

J. Mahajna; N. Dotan; B. Z. Zaidman; R. D. Petrova; S. P. Wasser
Nutrition and Cancer 2009 Volume 61 Issue 1 Pages 16-26
2009

Marasmius oreades substances block NF-κB activity through interference with IKK activation pathway

R. D. Petrova; J. Mahajna; S. P. Wasser; N. Ruimi; C. M. Denchev; S. Sussan; E. Nevo; A. Z. Reznick
Molecular Biology Reports 2009 Volume 36 Issue 4 Pages 737-744
2009

Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells

B. Z. Zaidman; S. P. Wasser; E. Nevo; J. Mahajna
Molecular Biology Reports 2008 Volume 35 Issue 2 Pages 107-117
2008

Fungal metabolites modulating NF-κB activity: An approach to cancer therapy and chemoprevention (review)

R. D. Petrova; A. Z. Reznick; S. P. Wasser; C. M. Denchev; E. Nevo; J. Mahajna
Oncology Reports 2008 Volume 19 Issue 2 Pages 299-308
2008

Substances from the medicinal mushroom Daedalea gibbosa inhibit kinase activity of native and T315I mutated Bcr-Abl

M. Yassin; S. P. Wasser; J. Mahajna
International Journal of Oncology 2008 Volume 32 Issue 6 Pages 1197-1204
2008

Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells

B. Z. Zaidman; S. P. Wasser; E. Nevo; J. Mahajna
International Journal of Oncology 2007 Volume 31 Issue 4 Pages 959-967
2007

Fungal substances as modulators of NF-κB activation pathway

R. D. Petrova; J. Mahajna; A. Z. Reznick; S. P. Wasser; C. M. Denchev; E. Nevo
Molecular Biology Reports 2007 Volume 34 Issue 3 Pages 145-154
2007

Inhibitory Effects of Marasminus oreades extract Fractions on NF-kB Activation Pathway.

Petrova, R. D., Ruimi, N., Sussan, S., Wasser, S.P., Nevo, E., Reznick, A.Z., and Mahajna, J.
.Intl. J. Med. Mush 2007 Volume 9 Issue 3 Pages 339-340.
2007

Mushroom secondary metabolites as modulators of NF-kB activation pathway.

Petrova D.R., Mahajna, J., Reznick, A.Z., Wasser, S.P., Denchev, M.C.and Nevo, E.
Mol Biol Rep. 2007 Volume 34 Pages 145-54.
2007

Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells

B. Z. Zaidman; A. Lutin; S. P. Wasser; E. Nevo; J. A. Mahajna
International Journal of Medicinal Mushrooms 2007 Volume 9 Issue 1 Pages 39-46
2007

The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene

A. Konson; J. A. Mahajna; A. Danon; G. Rimon; R. Agbaria
Cancer Gene Therapy 2006 Volume 13 Issue 12 Pages 1093-1104
2006

Screening Antitumor Activity of Low-Molecular-Weight Compounds Obtained from the Fruit Bodies of Family Agaricaceae Chevall. (Higher Basidiomycetes).

Didukh, Y. M., Wasser, S.P., Nevo, E. & Mahajna, J.
Intern. J. Med. Mush. 2005 Volume 7 Pages 398-400.
2005

Medicinal mushroom modulators of molecular targets as cancer therapeutics

B. Z. Zaidman; M. Yassin; J. Mahajna; S. P. Wasser
Applied Microbiology and Biotechnology 2005 Volume 67 Issue 4 Pages 453-468
2005

Medicinal Mushroom Substances As Cancer Molecular Therapy.

Mahajna, J., Yassin, M., Zaidman, B-Z., Nevo, E. and Wasser, S.P.
Intern. J. Med. Mush. 2005 Volume 7 Pages 352
2005

Medicinal Mushrooms: A New Source for Breast Cancer Therapeutics

Petrova, D.R., Wasser, S.P., Mahajna, J., Cvetomir M. Denchev, M.C. & Nevo, E.
Intern. J. Med. Mush. 2005 Volume 7 Pages 445-446.
2005

Potential role of medicinal mushrooms in breast cancer treatment: Current knowledge and future perspectives

R. D. Petrova; S. P. Wasser; J. A. Mahajna; C. M. Denchev; E. Nevo
International Journal of Medicinal Mushrooms 2005 Volume 7 Issue 01-??? Pages 141-155
2005