Cellular Immunotherapy & SynBio

Our mission is to pioneer cutting-edge genetic technologies inspired by the mechanisms of the immune system, with the goal of developing advanced cell therapies for a broad spectrum of diseases. Leveraging the latest tools in synthetic biology—including logic gates, genetic switches, and genetic adjuvants—we strive to design programmable, precise, and safe therapeutic solutions that redefine the boundaries of personalized medicine.

Dr Hadas Weinstein-Marom

Cellular Immunotherapy and Synthetic Biology Lab at MIGAL Institute is focused on two major research arms: 

  • adoptive T cell therapy of cancer, developing new logic gated strategies, genetic switches and composite adjuvants for accurate, selective and effective immunotargeting of tumors; 
  • genetic engineering of regulatory T cells and their reprogramming for the treatment of selected inflammatory and autoimmune diseases.

Principal Researcher

team members

Latest Publications

Cannabidiol polarizes human neutrophils toward a cancer-promoting phenotype

Mona Khoury, Yuxiang Hong, Dayana Blokon-Kogan, Stela Gengrinovitch, Harel Eitam, Moran Avraham-Kelbert, Hadas Weinstein-Marom, Peng Xu, Idan Cohen, Gil Bar-Sela
Read Online
Dr Hadas Weinstein-Marom
Front. Immunol., 25 July 2025
2025

CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens

Feigelson, S. W., Dadosh, T., Sapoznikov, A., Weinstein-Marom, H., Blokon-Kogan, D., Avraham, Y., Unger, T., Gross, G., Dahan, R. and Alon. R.
Read Online
Dr Hadas Weinstein-Marom, Prof. Gideon Gross
Front. Immunol., Vol. 15.
2025

Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

Kakabadse, D., Chen, D., Fishman, S., Weinstein-Marom, H., Davies, J., Wen, L., Gross, G. & Wong, F.S.
Read Online
Dr. Sigal Fishman , Prof. Gideon Gross, Dr Hadas Weinstein-Marom
Frontiers in Immunology. 15:1463971
2024

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

Dawei Chen, Dimitri Kakabadse, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Joanne Boldison, Terri C Thayer, Li Wen, Gideon Gross, F Susan Wong
Read Online
Dr Hadas Weinstein-Marom, Prof. Gideon Gross, Dr. Sigal Fishman 
Front. Immunol. Sep. 4.
2023
More Publications

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