Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges

A deep characterization of the molecular mechanisms responsible for atherosclerotic plaque development is needed.
RNAs and particularly non-coding RNAs regulate gene expression and play a major role in atherosclerotic plaque development.
Methodological challenges in transcriptomic studies hinder the translation of basic research findings to clinics.
Tips and tricks are provided to improve translational capacity of basic transcriptomic research for patient’s benefit.