Dr. Andrea Szuchman-Sapir : Vascular Signaling Research
EPA-lactone derivative, 5,6-diHETE lactone, improves pulmonary arterial hypertension in a monocrotaline-induced model
Karthik Dhananjayan, Offir Ertracht, Shaul Atar, Alejandro Livoff, Mona Shehadeh, Andrea Szuchman-Sapir
2025
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Front. Pharmacol., 10 July 2025
5, 6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP3 signaling pathway
Asulin, M., Gorodetzer, N., Fridman, R., Ben-Shushan, R. S., Cohen, Z., Beyer, A., Chuyun, D.,Gutterman, D., Szuchman-Sapir
2024
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Biochem. Biophys. Res. Comm., 700; 149585
Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern
Slutsky Smith EA, Khatib S, Szuchman-Sapir A.
2022
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Journal of Chromatography B, 1197:123201
Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation
Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, Chuyun D, Szuchman-Sapir A.
2022
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Prostaglandins & Other Lipid Mediators
Volume 162, October 2022, 106665
Volume 162, October 2022, 106665
Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats
Barsheshet M, Ertracht O, Boginya A, Reuveni T, Shaul A, Szuchman-Sapir A.
2021
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1866(12):159031
The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells
Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
2020
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Free Radical Biology and Medicine
Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.
Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A.
2018
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.
Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
2017
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FRBM 2017 Volume 103 Pages 87?94
In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.
Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
2017
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PLoS One 2017 Volume 24 Issue 5 Pages 1-14
Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation
Yehuda I, Madar Z, Leikin-Frenkel A, Szuchman-Sapir A, Magzal F, Markman G, Tamir S
2016
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Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99
Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin.
Wang XS , Kim HB , Szuchman-Sapir A , McMahon A , Dennis JM , Witting PK.
2016
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Archives of Biochemistry and Biophysics 2016 Volume 612 Pages 103-114
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1
Eryanni S, Khatib S, Levi-Rosenzvig R, Tamir S, Szuchman-Sapir A
2015
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BBA Molecular and Cell Biology of Lipids 2015 Volume 1851 Pages 1118-1122
Human atherosclerotic plaque lipid extract impairs the antioxidant defense capacity of monocytes
A. Szuchman-Sapir; M. Etzman; S. Tamir
2012
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Biochemical and Biophysical Research Communications 2012 Volume 423 Issue 4 Pages 884-888
Human atherosclerotic plaque lipid extract promotes expression of proinflammatory factors in human monocytes and macrophage-like cells
H. Yehuda; A. Szuchman-Sapir; S. Khatib; R. Musa; S. Tamir
2011
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Atherosclerosis 2011 Volume 218 Issue 2 Pages 339-343
Oxysterols formation as a reflection of biochemical pathways: summary of in-vitro and in-vivo studies
Jacob Vaya, Andrea Szuchman, Hagai Tavori, Yuval Aluf
2011
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Chemistry and Physics Lipids 2011 Volume 164 Issue 6 Pages 438-42
Glabridin, a phytoestrogen from licorice root, up-regulates the intracellular antioxidant defense mechanism under glucose stress
Itamar Yehuda1, Zecharia Madar 2, Andrea Szuchman-Sapir1, Snait Tamir 1, 3.
2011
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Phytotherapy Research 2011 Volume 25 Issue 5 Pages 659-67
Site ?specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction
Andrea Szuchman-Sapir,* David I. Pattison,? Michael J. Davies,? Paul K. Witting*
2010
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FRBM 2010 Volume 48 Issue 11 Pages 35-46
Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin
Szuchman-Sapir A, Pattison DI, Ellis NA, Hawkins CL, Davies MJ, Witting PK
2008
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FRBM. 2008 Issue 45 Pages 789-98
Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice
Witting P, Zeng B, Wong M, McMahon AC, Rayner BS, Sapir AJ, Lowe HC, Freedman SB, Brieger DB
2008
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Tromb Res. 2008 Issue 122 Pages 674-82
Characterization of oxidative stress in blood from diabetic versus hypercholesterolemic patients, using a novel synthesized marker
Szuchman A, Aviram M, Musa R, Soliman K, Vaya J.
2007
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Biomarkers 2007 Volume 30 Pages 1-13
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages
A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
2006
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Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages
A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
2006
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Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52
Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: Studies in various oxidative systems
A. Szuchman; M. Aviram; S. Tamir; J. Vaya
2003
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Free Radical Research 2003 Volume 37 Issue 12 Pages 1277-1288