Dr. Andrea Szuchman-Sapir

Dr. Andrea Szuchman-Sapir
Researcher, PI
Head of The Department of Nutrition and Natural Products
Head of Department
Research Group Leader
Endothelial dysfunction; EDHF; CYP-epoxygenase; vascular dilation; PON1; PUFA

Our research focuses on elucidation signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).

Current projects aimed to elucidate the role of cytochrome P450-derived specific lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.


Ph.D. 2006, Technion Faculty of Medicine, Haifa, Israel.

M.Sc. 2000, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Academic and research positions

2017-present, Head of the Laboratory of vascular signaling research, Migal-Galilee Research Institute

2017-present, Head of the Institutional Review Board (IRB) at the Tel-Hai College, Israel                            

2016-present, Senior lecturer at the Tel-Hai College, Israel 

2009-2016 Scientist at the Human Health & Nutrition Sciences laboratory, Migal-Galilee Research Institute 

2007-2009: Post-Doctoral at the Vascular Biology Group, ANZAC Research Institute, Concord Hospital, in collaboration with the Heart Research Institute, Sydney, Australia.

Research Grants   

2018-2020: Arterial dilating activity of an EPA metabolite, a novel endothelial-derived hyperpolarizing factor (EDHF), as an antihypertensive drug candidate. Israel Innovation Authority. In collaboration with Prof. Shaul Atar, Galilee Medical Center, Nahariya. 

2016-2018: PON1 regulates blood pressure via EDHF. BSF- start-up grant. In collaboration with Prof. Gutterman David, Medical College of Wisconsin, Milwaukee, USA.

2015-2018: The regulation of 5,6-DHTL, a new endothelial-derived hyperpolarizing factor, by paraoxonase 1 in the modulation of vascular tone. ISF- Israel Science Foundation research fellowship.

2012-2015: A novel pathway for blood pressure regulation involving paraoxonase 1 and epoxygenase arachidonic acid metabolites. ISF - Israel Science Foundation research fellowship.

2012-2013: The Israeli Society for Research, Prevention, and Treatment of Atherosclerosis.


Scientific Publications

Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern

Slutsky Smith EA, Khatib S, Szuchman-Sapir A.
Journal of Chromatography B, 1197:123201

Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation

Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, Chuyun D, Szuchman-Sapir A.
Prostaglandins & Other Lipid Mediators
Volume 162, October 2022, 106665

Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats

Barsheshet M, Ertracht O, Boginya A, Reuveni T, Shaul A, Szuchman-Sapir A.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1866(12):159031

The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells

Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
Free Radical Biology and Medicine

Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.

Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A.

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.

Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
FRBM 2017 Volume 103 Pages 87?94

In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.

Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
PLoS One 2017 Volume 24 Issue 5 Pages 1-14

Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation

Yehuda I, Madar Z, Leikin-Frenkel A, Szuchman-Sapir A, Magzal F, Markman G, Tamir S
Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99

Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin.

Wang XS , Kim HB , Szuchman-Sapir A , McMahon A , Dennis JM , Witting PK.
Archives of Biochemistry and Biophysics 2016 Volume 612 Pages 103-114

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1

Eryanni S, Khatib S, Levi-Rosenzvig R, Tamir S, Szuchman-Sapir A
BBA Molecular and Cell Biology of Lipids 2015 Volume 1851 Pages 1118-1122

Human atherosclerotic plaque lipid extract impairs the antioxidant defense capacity of monocytes

A. Szuchman-Sapir; M. Etzman; S. Tamir
Biochemical and Biophysical Research Communications 2012 Volume 423 Issue 4 Pages 884-888

Glabridin, a phytoestrogen from licorice root, up-regulates the intracellular antioxidant defense mechanism under glucose stress

Itamar Yehuda1, Zecharia Madar 2, Andrea Szuchman-Sapir1, Snait Tamir 1, 3.
Phytotherapy Research 2011 Volume 25 Issue 5 Pages 659-67

Human atherosclerotic plaque lipid extract promotes expression of proinflammatory factors in human monocytes and macrophage-like cells

H. Yehuda; A. Szuchman-Sapir; S. Khatib; R. Musa; S. Tamir
Atherosclerosis 2011 Volume 218 Issue 2 Pages 339-343

Oxysterols formation as a reflection of biochemical pathways: summary of in-vitro and in-vivo studies

Jacob Vaya, Andrea Szuchman, Hagai Tavori, Yuval Aluf
Chemistry and Physics Lipids 2011 Volume 164 Issue 6 Pages 438-42

Site ?specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction

Andrea Szuchman-Sapir,* David I. Pattison,? Michael J. Davies,? Paul K. Witting*
FRBM 2010 Volume 48 Issue 11 Pages 35-46

Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice

Witting P, Zeng B, Wong M, McMahon AC, Rayner BS, Sapir AJ, Lowe HC, Freedman SB, Brieger DB
Tromb Res. 2008 Issue 122 Pages 674-82

Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

Szuchman-Sapir A, Pattison DI, Ellis NA, Hawkins CL, Davies MJ, Witting PK
FRBM. 2008 Issue 45 Pages 789-98

Characterization of oxidative stress in blood from diabetic versus hypercholesterolemic patients, using a novel synthesized marker

Szuchman A, Aviram M, Musa R, Soliman K, Vaya J.
Biomarkers 2007 Volume 30 Pages 1-13

Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages

A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52

Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages

A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52

Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: Studies in various oxidative systems

A. Szuchman; M. Aviram; S. Tamir; J. Vaya
Free Radical Research 2003 Volume 37 Issue 12 Pages 1277-1288