Our research focuses on elucidation signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).
Current projects aimed to elucidate the role of cytochrome P450-derived specific lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.
Ph.D. 2006, Technion Faculty of Medicine, Haifa, Israel.
M.Sc. 2000, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Academic and research positions
2017-present, Head of the Laboratory of vascular signaling research, Migal-Galilee Research Institute
2017-present, Head of the Institutional Review Board (IRB) at the Tel-Hai College, Israel
2016-present, Senior lecturer at the Tel-Hai College, Israel
2009-2016 Scientist at the Human Health & Nutrition Sciences laboratory, Migal-Galilee Research Institute
2007-2009: Post-Doctoral at the Vascular Biology Group, ANZAC Research Institute, Concord Hospital, in collaboration with the Heart Research Institute, Sydney, Australia.
2018-2020: Arterial dilating activity of an EPA metabolite, a novel endothelial-derived hyperpolarizing factor (EDHF), as an antihypertensive drug candidate. Israel Innovation Authority. In collaboration with Prof. Shaul Atar, Galilee Medical Center, Nahariya.
2016-2018: PON1 regulates blood pressure via EDHF. BSF- start-up grant. In collaboration with Prof. Gutterman David, Medical College of Wisconsin, Milwaukee, USA.
2015-2018: The regulation of 5,6-DHTL, a new endothelial-derived hyperpolarizing factor, by paraoxonase 1 in the modulation of vascular tone. ISF- Israel Science Foundation research fellowship.
2012-2015: A novel pathway for blood pressure regulation involving paraoxonase 1 and epoxygenase arachidonic acid metabolites. ISF - Israel Science Foundation research fellowship.
2012-2013: The Israeli Society for Research, Prevention, and Treatment of Atherosclerosis.
Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern
Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation
Volume 162, October 2022, 106665