Dr. Andrea Szuchman-Sapir

Dr. Andrea Szuchman-Sapir
Principal Investigator
Researcher, PI
Vascular Signaling Research
Endothelial cells; EDHF; CYP-epoxygenase; vascular dilation; PON1; PUFA

Our research focuses on elucidation signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).

Current projects aimed to elucidate the role of cytochrome P450-derived specific lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.


Ph.D. 2006, Technion Faculty of Medicine, Haifa, Israel.

M.Sc. 2000, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Academic and research positions

2017- Head of the Laboratory of vascular signaling research, Migal-Galilee Research Institute

2017- Head of the IRB committee at the Tel-Hai College, Israel                            

Since 2011: Faculty member, Tel-Hai academic college, Israel

2009-2016 Scientist at the Human Health & Nutrition Sciences laboratory, Migal-Galilee Research Institute 

Since 2016: Senior lecturer at the Tel-Hai College, Israel 

2007-2009: Post-Doctoral at the Vascular Biology Group, ANZAC Research Institute, Concord Hospital, in collaboration with the Heart Research Institute, Sydney, Australia.

Research Grants   

2018-2020: Arterial dilating activity of an EPA metabolite, a novel endothelial-derived hyperpolarizing factor (EDHF), as an antihypertensive drug candidate. Israel Innovation Authority. In collaboration with Prof. Shaul Atar, Galilee Medical Center, Nahariya. 

2016-2018: PON1 regulates blood pressure via EDHF. BSF- start-up grant. In collaboration with Prof. Gutterman David, Medical College of Wisconsin, Milwaukee, USA.

2015-2018: The regulation of 5,6-DHTL, a new endothelial-derived hyperpolarizing factor, by paraoxonase 1 in the modulation of vascular tone. ISF- Israel Science Foundation research fellowship.

2012-2015: A novel pathway for blood pressure regulation involving paraoxonase 1 and epoxygenase arachidonic acid metabolites. ISF - Israel Science Foundation research fellowship.

2012-2013: The Israeli Society for Research, Prevention, and Treatment of Atherosclerosis.

Other Activity and Service

Since 2017: Chairman of the Tel-Hai Institutional Review Board (IRB) for human subject research.

2013-2017: Treasurer of the Israeli Society for Oxygen and Free Radical Research.

Since 2011: Active scientist at the "European Researcher's - Night", MIGAL Research Institute.

Scientific Publications

The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells

Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
Free Radical Biology and Medicine

Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.

Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A.

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.

Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
FRBM 2017 Volume 103 Pages 87?94

In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.

Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
PLoS One 2017 Volume 24 Issue 5 Pages 1-14

Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation

Yehuda I, Madar Z, Leikin-Frenkel A, Szuchman-Sapir A, Magzal F, Markman G, Tamir S
Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99