Vascular Signaling Research

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).

Dr. Andrea Szuchman-Sapir

Title
Overview

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.

 

Video Lecture: "Molecular regulation of endothelial and vascular dysfunction by PUFA – derived lactone Mediators" by Szuchman – Sapir Andrea

Video file

 

Principal Researcher

Team

Nadav Gorodetzer

M.Sc in Nutrition. Tel-Hai College
Research Interests:

Potential receptors through which PUFA-lactone molecules induce hyperpolarization in endothelial cell.

Pozy22@gmail.com

Zohar Cohen

M.Sc in Biotechnology. Tel-Hai College
Research Interests:

Nanoencapsulated PUFA-lactones for the treatment of endothelial dysfunction

zoharc268@gmail.com

Collaborations

Collaborations
Netanel Korin- Technion – Israel Institute of Technology
Gutterman David- Medical College of Wisconsin, USA
Atar Shaul- Director of Cardiology, Galilee Medical Center, Israel
Offir Ertracht- Cardiovascular Research Laboratory, Research Institute, Galilee…

Funding

Funding
Patents
In the name of Gavish-Galilee Bio Applications Ltd. : "EPA-lactone for treatment of microvascular dysfunction" Ref.: GAVISH-118 PCT
In the lab
142900
Ortho
In conference
Trip2
Nadav

Latest Publications

EPA-lactone derivative, 5,6-diHETE lactone, improves pulmonary arterial hypertension in a monocrotaline-induced model

Karthik Dhananjayan, Offir Ertracht, Shaul Atar, Alejandro Livoff, Mona Shehadeh and Andrea Szuchman-Sapir
Read Online
Dr. Andrea Szuchman-Sapir
Front Pharmacol. 2025 Jul
2025

5, 6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP3 signaling pathway

Asulin, M., Gorodetzer, N., Fridman, R., Ben-Shushan, R. S., Cohen, Z., Beyer, A., Chuyun, D.,Gutterman, D., Szuchman-Sapir‏
Read Online
Dr. Andrea Szuchman-Sapir, Nadav Gorodetzer, Zohar Cohen
Biochem. Biophys. Res. Comm., 700; 149585
2024

Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern

Slutsky Smith EA, Khatib S, Szuchman-Sapir A.
Read Online
Dr. Andrea Szuchman-Sapir
Journal of Chromatography B, 1197:123201
2022

Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation

Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, Chuyun D, Szuchman-Sapir A.
Read Online
Dr. Andrea Szuchman-Sapir
Prostaglandins & Other Lipid Mediators
Volume 162, October 2022, 106665
2022
More Publications

Lab News

Open positions

We are recruiting Ph.D. and M.Sc. curious students with the background in biotechnology, Nutrition, Life-sciences.

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