Vascular Signaling Research

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).

Dr. Andrea Szuchman-Sapir

Title
Overview

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.

 

Video Lecture: "Molecular regulation of endothelial and vascular dysfunction by PUFA – derived lactone Mediators" by Szuchman – Sapir Andrea

Video file

 

Principal Researcher

Team

Nadav Gorodetzer

M.Sc in Nutrition. Tel-Hai College
Research Interests:

Potential receptors through which PUFA-lactone molecules induce hyperpolarization in endothelial cell.

Zohar Cohen

M.Sc in Biotechnology. Tel-Hai College
Research Interests:

Nanoencapsulated PUFA-lactones for the treatment of endothelial dysfunction

Collaborations

Funding

Patents
In the name of Gavish-Galilee Bio Applications Ltd. : "EPA-lactone for treatment of microvascular dysfunction" Ref.: GAVISH-118 PCT

Latest Publications

Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern

Slutsky Smith EA, Khatib S, Szuchman-Sapir A.
Journal of Chromatography B, 1197:123201
2022

Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation

Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, Chuyun D, Szuchman-Sapir A.
Prostaglandins & Other Lipid Mediators
Volume 162, October 2022, 106665
2022

Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats

Barsheshet M, Ertracht O, Boginya A, Reuveni T, Shaul A, Szuchman-Sapir A.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1866(12):159031
2021

The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells

Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
Free Radical Biology and Medicine
2020

Lab News

Open positions

We are recruiting Ph.D. and M.Sc. curious students with the background in biotechnology, Nutrition, Life-sciences.

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