Dr. Andrea Szuchman-Sapir : Vascular Signaling Research

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).
Overview

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.

 

Video Lecture: "Molecular regulation of endothelial and vascular dysfunction by PUFA – derived lactone Mediators" by Szuchman – Sapir Andrea

Video file

 

RESEARCH TEAM

Nadav Gorodetzer

M.Sc in Nutrition. Tel-Hai College
Reseach Intrerest

Potential receptors through which PUFA-lactone molecules induce hyperpolarization in endothelial cell.

Pozy22@gmail.com

Zohar Cohen

M.Sc in Biotechnology. Tel-Hai College
Reseach Intrerest

Nanoencapsulated PUFA-lactones for the treatment of endothelial dysfunction

zoharc268@gmail.com
Collaborations
Netanel Korin- Technion – Israel Institute of Technology
Gutterman David- Medical College of Wisconsin, USA
Atar Shaul- Director of Cardiology, Galilee Medical Center, Israel
Offir Ertracht- Cardiovascular Research Laboratory, Research Institute, Galilee…
Funding
Funding