The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.
Video Lecture: "Molecular regulation of endothelial and vascular dysfunction by PUFA – derived lactone Mediators" by Szuchman – Sapir Andrea
Principal Researcher
Dr. Andrea Szuchman-Sapir
Our research focuses on elucidation signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizin
Latest Publications
Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern
Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation
Volume 162, October 2022, 106665