Vascular Signaling Research

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated.