The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).
Principal Researcher
Dr. Andrea Szuchman-Sapir
Vascular Signaling Research
972-4-6955029
Our research focuses on elucidation signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizin
Team
Karthik Dhananjayan
Ph.D. Post-Doctoral fellow
Research Interests:
Restoring vascular function in pulmonary hypertension by PUFA lactones
Nadav Gorodetzer
M.Sc in Nutrition. Tel-Hai College
Research Interests:
Potential receptors through which PUFA-lactone molecules induce hyperpolarization in endothelial cell.
Zohar Cohen
M.Sc in Biotechnology. Tel-Hai College
Research Interests:
Nanoencapsulated PUFA-lactones for the treatment of endothelial dysfunction
Collaborations
Funding
Patents
In the name of Gavish-Galilee Bio Applications Ltd. : "EPA-lactone for treatment of microvascular dysfunction" Ref.: GAVISH-118 PCT
Latest Publications
Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern
Journal of Chromatography B, 1197:123201
2022
Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation
Prostaglandins & Other Lipid Mediators
Volume 162, October 2022, 106665
Volume 162, October 2022, 106665
2022
Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1866(12):159031
2021
The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells
Free Radical Biology and Medicine
2020
Lab News
Open positions
We are recruiting Ph.D. and M.Sc. curious students with the background in biotechnology, Nutrition, Life-sciences.