Vascular Signaling Research
- Vascular Signaling Research
- Vascular Signaling Research
Dr. Andrea Szuchman-Sapir
5, 6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP3 signaling pathway
Asulin, M., Gorodetzer, N., Fridman, R., Ben-Shushan, R. S., Cohen, Z., Beyer, A., Chuyun, D.,Gutterman, D., Szuchman-Sapir
Biochem. Biophys. Res. Comm., 700; 149585
2024
Fishing for lipid lactones using selective reaction and characteristic fragmentation pattern
Slutsky Smith EA, Khatib S, Szuchman-Sapir A.
Journal of Chromatography B, 1197:123201
2022
Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation
Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, Chuyun D, Szuchman-Sapir A.
Prostaglandins & Other Lipid Mediators
Volume 162, October 2022, 106665
Volume 162, October 2022, 106665
2022
Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats
Barsheshet M, Ertracht O, Boginya A, Reuveni T, Shaul A, Szuchman-Sapir A.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1866(12):159031
2021
The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells
Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
Free Radical Biology and Medicine
2020
Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.
Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A.
2018
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.
Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
FRBM 2017 Volume 103 Pages 87?94
2017
In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.
Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
PLoS One 2017 Volume 24 Issue 5 Pages 1-14
2017
Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation
Yehuda I, Madar Z, Leikin-Frenkel A, Szuchman-Sapir A, Magzal F, Markman G, Tamir S
Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99
2016
Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin.
Wang XS , Kim HB , Szuchman-Sapir A , McMahon A , Dennis JM , Witting PK.
Archives of Biochemistry and Biophysics 2016 Volume 612 Pages 103-114
2016
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1
Eryanni S, Khatib S, Levi-Rosenzvig R, Tamir S, Szuchman-Sapir A
BBA Molecular and Cell Biology of Lipids 2015 Volume 1851 Pages 1118-1122
2015
Human atherosclerotic plaque lipid extract impairs the antioxidant defense capacity of monocytes
A. Szuchman-Sapir; M. Etzman; S. Tamir
Biochemical and Biophysical Research Communications 2012 Volume 423 Issue 4 Pages 884-888
2012
Human atherosclerotic plaque lipid extract promotes expression of proinflammatory factors in human monocytes and macrophage-like cells
H. Yehuda; A. Szuchman-Sapir; S. Khatib; R. Musa; S. Tamir
Atherosclerosis 2011 Volume 218 Issue 2 Pages 339-343
2011
Oxysterols formation as a reflection of biochemical pathways: summary of in-vitro and in-vivo studies
Jacob Vaya, Andrea Szuchman, Hagai Tavori, Yuval Aluf
Chemistry and Physics Lipids 2011 Volume 164 Issue 6 Pages 438-42
2011
Glabridin, a phytoestrogen from licorice root, up-regulates the intracellular antioxidant defense mechanism under glucose stress
Itamar Yehuda1, Zecharia Madar 2, Andrea Szuchman-Sapir1, Snait Tamir 1, 3.
Phytotherapy Research 2011 Volume 25 Issue 5 Pages 659-67
2011
Site ?specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction
Andrea Szuchman-Sapir,* David I. Pattison,? Michael J. Davies,? Paul K. Witting*
FRBM 2010 Volume 48 Issue 11 Pages 35-46
2010
Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice
Witting P, Zeng B, Wong M, McMahon AC, Rayner BS, Sapir AJ, Lowe HC, Freedman SB, Brieger DB
Tromb Res. 2008 Issue 122 Pages 674-82
2008
Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin
Szuchman-Sapir A, Pattison DI, Ellis NA, Hawkins CL, Davies MJ, Witting PK
FRBM. 2008 Issue 45 Pages 789-98
2008
Characterization of oxidative stress in blood from diabetic versus hypercholesterolemic patients, using a novel synthesized marker
Szuchman A, Aviram M, Musa R, Soliman K, Vaya J.
Biomarkers 2007 Volume 30 Pages 1-13
2007
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages
A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52
2006
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages
A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52
2006
Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: Studies in various oxidative systems
A. Szuchman; M. Aviram; S. Tamir; J. Vaya
Free Radical Research 2003 Volume 37 Issue 12 Pages 1277-1288
2003