Prof. Gideon Gross : Immunology

Dr Hadas Weinstein-Marom, Dr. Sigal Fishman , Prof. Gideon Gross

Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

Kakabadse, D., Chen, D., Fishman, S., Weinstein-Marom, H., Davies, J., Wen, L., Gross, G. & Wong, F.S.

2024 , Frontiers in Immunology. 15:1463971

Dr. Sigal Fishman , Prof. Gideon Gross

Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes

Kakabadse, D., Chen, D., Fishman, S., Weinstein-Marom, H., Davies, J., Wen, L., Gross, G. & Wong, F.S.

2024 , Frontiers in Immunology. 15:1463971

Dr Hadas Weinstein-Marom, Prof. Gideon Gross, Dr. Sigal Fishman

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

Dawei Chen, Dimitri Kakabadse, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Joanne Boldison, Terri C Thayer, Li Wen, Gideon Gross, F Susan Wong

2023 , Front. Immunol. Sep. 4.

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

Blokon-Kogan, D., Levi- Mann, D., Malka-Levy, L., Itzhaki, O., Besser, M.J., Shiftan, Y., Szöőr, Á., Vereb, G., Gross, G., Abken, H. and Weinstein-Marom, H.

2022 , J. Immunother. Cancer, July 23.

The Intracellular Domain of CD40 is a Potent Costimulatory Element in Chimeric Antigen Receptors

Ofir Levin-Piaeda, Noam Levin, Sarah Pozner, Adi Danieli, Hadas Weinstein-Marom, Gideon Gross

2021 , J. Immunother., 44, 209-213.

Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction

Weinstein-Marom, H., Gross, G., Levi, M., Brayer, H., Schachter, J., Itzhaki, O., and Besser, M.J.

2021 , Front. Immunol., Vol. 11.

Implementing Logic Gates for Safer Immunotherapy of Cancer

Mohammed Azharuddin Savanur, Hadas Weinstein-Marom, Gideon Gross

2021 , Front. Immunol. Nov 4; 12:780399.

Combined expression of genetic adjuvants exerts multiple immunostimulatory effects on antitumor T cells.

Weinstein-Marom, H., Levin, N., Pato, A., Peretz, T., Eisenberg, G., Lotem, M., Itzhaki, O., Besser, M.J. and Gross, G.
J. Immunother. 42, 43-50. 2019

2019 , J. Immunother. 42, 43-50.

Endowing human CD8 T cells with a veto-like recognition capacity via the electroporation of MHC-I/CD3zeta mRNA.

Weissberg, O. and Gross, G.

Transpl. Immuno., Aug;55:101202, 2019

2019

MHC-I presentation of distinct antigenic peptides derived from protein products of the pioneer round of translation

Weinstein-Marom, H., Hendel, L., Avigad-Laron, E., Margalit, A. and Gross, G.

2019 , FASEB. J. 33, 11458-11468.

Potent activation of human T cells by mRNA encoding constitutively active CD40.

Levin, N., Weinstein-Marom, H., Pato, A., Itzhaki, O., Besser, M.J., Peretz, T., Eisenberg, G., Lotem, M. and Gross, G. (2018)
J. Immunology 201, 2959–2968

2018 , J. Immunology 201, 2959–2968.

Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes

Fishman, S., Mark D. Lewis, M. D., Siew, K., De Leenheer, E., Kakabadse, D., Davies, J., Ziv, D., Margalit, A., Karin, N., Gross, G.* and Wong, F. S.

2017 , Mol Ther. 2017 Volume 25 Issue 2 Pages 456?464.

Spontaneous activation of antigen-presenting cells by genes encoding truncated homo-oligomerizing derivatives of CD40

Levin, N., Pato, A., Cafri, G., Eisenberg, G., Peretz, T., Margalit, A., Lotem, M. and Gross, G.

2017 , J Immunother 2017 Volume 40 Issue 2 Pages 39-50

Therapeutic potential of T cell chimeric antigen receptors in cancer treatment: counteracting off-tumor toxicities for safe CAR T cell therapy.

2016 , Ann Rev. Pharm. Toxicol. 2016 Volume 56 Pages 59-83

Membrane-attached cytokines expressed by mRNA electroporation act as potent T cell adjuvants.

Weinstein-Marom, H., Pato, A., Levin, N., Susid, K., Itzhaki, O., Besser, M.J., Peretz, T., Margalit, A., Lotem, M. and Gross, G.

2016 , J. Immuother. 2016 Volume 39 Pages 60-70

A reproducible method for the expansion of mouse CD8+ T lymphocytes.

Lewis, M. D., de Leenheer, E., Fishman, S., Siew, L. K., G. Gross, G. and Wong, F.S.

2015 , J. Immunol. Methods 2015 Issue 417 Pages 134-138

Efficient peptide recovery from secreted recombinant MHC-I molecules expressed via mRNA transfection.

Lazarus, D., Weinstein-Marom, H., Fishman, S., Yossef, Y., Zuri, D,. Barnea, E., Admon, A., Margalit, A. and G. Gross, G.

2015 , Immunol. Lett. 2015 Volume 165 Pages 32-38

Messenger RNA encoding constitutively active toll-like receptor 4 enhances effector functions of human T cells.

Pato, A., Eisenberg, G., Machlenkin, A., Margalit, S., Cafri, G., Frankenburg, S., Merims, S., Peretz, T., Lotem, M. and Gross, G.

2015 , Clin. Exp. Immunol. 2015 Volume 182 Issue 2 Pages 220-229

The emergence of T-bodies / CAR T cells

Eshhar, Z, Waks, T. and Gross, G.

2014 , Cancer J. 2014 Volume 20 Pages 123-126

Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells

Perez, S., Fishman, S., Margalit, A., Wong, F. S. and Gross, G.

2014 , Immunology 2014 Volume 143 Pages 609-17

Development of novel genetic cancer vaccines based on membrane-attached beta2 microglobulin

Cafri, G., Margalit, SA., Tzehoval, E., Eisenbach L. and Gross, G.

2013 , Ann. N.Y. Acad. Sci. 2013 Volume 1283 Pages 87-90

Coupling presentation of MHC class I peptides to constitutive activation of antigen-presenting cells through the product of a single gene

G. Cafri; E. Amram; G. Rinott; G. Koifman; S. Fishman; Y. Keisari; E. Tzehoval; A. Margalit; L. Eisenbach; G. Gross

2011 , International Immunology 2011 Volume 23 Issue 7 Pages 453-461

Immunotargeting of insulin reactive CD8 T cells to prevent Diabetes

G. S. Scott; S. Fishman; L. Khai Siew; A. Margalit; S. Chapman; A. V. Chervonsky; L. Wen; G. Gross; F. Susan Wong

2010 , Journal of Autoimmunity 2010 Volume 35 Issue 4 Pages 390-397

Enhanced HIV-1 neutralization by a CD4-VH3-IgG1 fusion protein

R. Meyuhas; H. Noy; S. Fishman; A. Margalit; D. C. Montefiori; G. Gross

2009 , Biochemical and Biophysical Research Communications 2009 Volume 386 Issue 2 Pages 402-406