Immunology Laboratory

Prof. Gideon Gross

Combined expression of genetic adjuvants exerts multiple immunostimulatory effects on antitumor T cells.

Weinstein-Marom, H., Levin, N., Pato, A., Peretz, T., Eisenberg, G., Lotem, M., Itzhaki, O., Besser, M.J. and Gross, G.
J. Immunother. 42, 43-50. 2019
2019

Endowing human CD8 T cells with a veto-like recognition capacity via the electroporation of MHC-I/CD3zeta mRNA.

Weissberg, O. and Gross, G.

Transpl. Immuno., Aug;55:101202, 2019
2019

MHC-I presentation of distinct antigenic peptides derived from protein products of the pioneer round of translation

Weinstein-Marom, H., Hendel, L., Avigad-Laron, E., Margalit, A. and Gross, G.
FASEB. J. 33, 11458-11468.
2019

MHC-I presentation of distinct antigenic peptides derived from protein products of the pioneer round of translation

Weinstein-Marom, H., Hendel, L., Avigad-Laron, E., Margalit, A. and Gross, G.
FASEB. J. 33, 11458-11468.
2019

Potent activation of human T cells by mRNA encoding constitutively active CD40.

Levin, N., Weinstein-Marom, H., Pato, A., Itzhaki, O., Besser, M.J., Peretz, T., Eisenberg, G., Lotem, M. and Gross, G.

J. Immunology 201, 2959–2968, 2018
2018

Potent activation of human T cells by mRNA encoding constitutively active CD40.

Levin, N., Weinstein-Marom, H., Pato, A., Itzhaki, O., Besser, M.J., Peretz, T., Eisenberg, G., Lotem, M. and Gross, G. (2018)
J. Immunology 201, 2959–2968
2018

Spontaneous activation of antigen-presenting cells by genes encoding truncated homo-oligomerizing derivatives of CD40

Levin, N., Pato, A., Cafri, G., Eisenberg, G., Peretz, T., Margalit, A., Lotem, M. and Gross, G.
J Immunother 2017 Volume 40 Issue 2 Pages 39-50
2017

Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes

Fishman, S., Mark D. Lewis, M. D., Siew, K., De Leenheer, E., Kakabadse, D., Davies, J., Ziv, D., Margalit, A., Karin, N., Gross, G.* and Wong, F. S.
Mol Ther. 2017 Volume 25 Issue 2 Pages 456?464.
2017

Membrane-attached cytokines expressed by mRNA electroporation act as potent T cell adjuvants.

Weinstein-Marom, H., Pato, A., Levin, N., Susid, K., Itzhaki, O., Besser, M.J., Peretz, T., Margalit, A., Lotem, M. and Gross, G.
J. Immuother. 2016 Volume 39 Pages 60-70
2016

Therapeutic potential of T cell chimeric antigen receptors in cancer treatment: counteracting off-tumor toxicities for safe CAR T cell therapy.

Ann Rev. Pharm. Toxicol. 2016 Volume 56 Pages 59-83
2016

Messenger RNA encoding constitutively active toll-like receptor 4 enhances effector functions of human T cells.

Pato, A., Eisenberg, G., Machlenkin, A., Margalit, S., Cafri, G., Frankenburg, S., Merims, S., Peretz, T., Lotem, M. and Gross, G.
Clin. Exp. Immunol. 2015 Volume 182 Issue 2 Pages 220-229
2015

A reproducible method for the expansion of mouse CD8+ T lymphocytes.

Lewis, M. D., de Leenheer, E., Fishman, S., Siew, L. K., G. Gross, G. and Wong, F.S.
J. Immunol. Methods 2015 Issue 417 Pages 134-138
2015

Efficient peptide recovery from secreted recombinant MHC-I molecules expressed via mRNA transfection.

Lazarus, D., Weinstein-Marom, H., Fishman, S., Yossef, Y., Zuri, D,. Barnea, E., Admon, A., Margalit, A. and G. Gross, G.
Immunol. Lett. 2015 Volume 165 Pages 32-38
2015

Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells

Perez, S., Fishman, S., Margalit, A., Wong, F. S. and Gross, G.
Immunology 2014 Volume 143 Pages 609-17
2014

The emergence of T-bodies / CAR T cells

Eshhar, Z, Waks, T. and Gross, G.
Cancer J. 2014 Volume 20 Pages 123-126
2014

Development of novel genetic cancer vaccines based on membrane-attached beta2 microglobulin

Cafri, G., Margalit, SA., Tzehoval, E., Eisenbach L. and Gross, G.
Ann. N.Y. Acad. Sci. 2013 Volume 1283 Pages 87-90
2013

Coupling presentation of MHC class I peptides to constitutive activation of antigen-presenting cells through the product of a single gene

G. Cafri; E. Amram; G. Rinott; G. Koifman; S. Fishman; Y. Keisari; E. Tzehoval; A. Margalit; L. Eisenbach; G. Gross
International Immunology 2011 Volume 23 Issue 7 Pages 453-461
2011

Immunotargeting of insulin reactive CD8 T cells to prevent Diabetes

G. S. Scott; S. Fishman; L. Khai Siew; A. Margalit; S. Chapman; A. V. Chervonsky; L. Wen; G. Gross; F. Susan Wong
Journal of Autoimmunity 2010 Volume 35 Issue 4 Pages 390-397
2010

Enhanced HIV-1 neutralization by a CD4-VH3-IgG1 fusion protein

R. Meyuhas; H. Noy; S. Fishman; A. Margalit; D. C. Montefiori; G. Gross
Biochemical and Biophysical Research Communications 2009 Volume 386 Issue 2 Pages 402-406
2009

Developing a novel model system to target insulin reactive CD8 T cells

Scott, G. S., Fishman, S., Margalit, A., Siew L. K., Chapman, S., Wen, L., Gross, G. & Wong, F. S.
Ann. N.Y. Acad. Sci. 2008 Volume 1150, Pages 54?58
2008

Targeting tumor-associated antigens to the MHC class I presentation pathway

G. Gross; A. Margalit
Endocrine, Metabolic and Immune Disorders - Drug Targets 2007 Volume 7 Issue 2 Pages 99-109
2007

Induction of anti-tumor immunity by CTL epitopes genetically linked to membrane- anchored beta2 microglobulin

Margalit, A., Migalovich Sheikhet, H., Carmi, Y., Berko, D., Tzehoval, E., Eisenbach, L. & Gross, G.
J. Immunol. 2006 Volume 176 Pages 217-224
2006

HIV-1 neutralization by chimeric CD4-CG10 polypeptides fused to human IgG1

R. Meyuhas; H. Noy; D. C. Montefiori; G. Denisova; J. M. Gershoni; G. Gross
Molecular Immunology 2005 Volume 42 Issue 9 Pages 1099-1109
2005

Membrane-anchored β2-microglobulin stabilizes a highly receptive state of MHC class I molecules

D. Berko; Y. Carmi; G. Cafri; S. Ben-Zaken; H. M. Sheikhet; E. Tzehoval; L. Eisenbach; A. Margalit; G. Gross
Journal of Immunology 2005 Volume 174 Issue 4 Pages 2116-2123
2005

In-cell generation of antibody single-chain Fv transcripts by targeted RNA trans-splicing

J. Schlesinger; D. Arama; H. Noy; M. Dagash; P. Belinky; G. Gross
Journal of Immunological Methods 2003 Volume 282 Pages 175-186
2003