Prof. Snait Tamir

Prof. Snait Tamir
Research Group Leader
Research Interests:

The microbial communities that colonize different regions of the human gut influence many aspects of health. Recent research has provided strong evidence for the role of the commensal gut microbiota in brain function and behavior. Bidirectional communication between gut microbiota and components of the gut–brain axis influence normal homeostasis and may contribute to risk of disease.

Diet is considered among the most crucial factors, which have an impact on microbial community composition from infancy to old age. Thus, dietary interventions may have the potential to modulate stress-response and overall behavior associated with gut–brain axis dysfunction and should open up new possibilities for health manipulation.

Among our main interests are:

  1. Investigating the effects of personalized, diet-induced alterations in microbiota on sleep quality in older adults.
  2. Exploring the associations between gut microbiota and geriatric depression, and the potential of a nutrition induced microbiota alterations diet, aimed to improve quality of life and wellbeing in older adults.
  3. Studying the effect and\or involvement of microbial metabolites on sleep, depression and ADHD.
  4. In addition, we are involved in two more studies dealing with microbiome. One, which deals with probiotic treatment for students with attention deficiency disorder, and the second, is concerned with the effect of probiotic supplementation on the ability to perform intense endurance exercises among master's runners and competitive cyclists.

Ph.D. 1991, Faculty of Agriculture, Department of Biochemistry and Human Nutrition, The Hebrew University of Jerusalem.

Academic and research positions
1992 - 1995 Postdoctoral research at the Department of Chemistry, Division of Toxicology, Massachusetts Institute of Technology, Cambridge, MA. USA.
1998 - 2003 Research associate, Laboratory of Natural Medicinal Compounds, MIGAL.
2001 - 2002 Head of the Biotechnology and Enviromental Science Dept. Tel Hai College.
1999 - 2005 Head of the Nutrition Science Department, Tel Hai College.
Since 2005 Head of Human Health and Nutritional Science Laboratory, MIGAL- Galilee Research Institute.
2006 - 2010 Dean of Sciences and Technology Faculty, Tel Hai College.
2013-2015  M.Sc Program Director, Dept. of Nutrition Sciences of the Faculty of Sciences and Technology, Tel Hai College.

Since 2018 Vice President of Academic Affairs, Tel Hai College>

Other Activity and Service
Since 1996 Clinical dietitian.

Scientific Publications

In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.

Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
PLoS One 2017 Volume 24 Issue 5 Pages 1-14

Long-lived weight-reduced ?MUPA mice show higher and longer maternal-dependent postnatal leptin surge

Mariel Pinsky, Maayan Rauch, Atallah Abbas, Adi Sharabi-Nov, Snait Tamir, Roee Gutman
PLoS ONE 2017 Volume 12 Issue 11

The effect of caffeine on energy balance

Harpaz E, Tamir S, Weinstein A and Weinstein Y.
J Basic Clin Physiol Pharmacol 2017 Volume 28 Issue 1 Pages 1-10

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.

Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
FRBM 2017 Volume 103 Pages 87?94

Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation

Yehuda I, Madar Z, Leikin-Frenkel A, Szuchman-Sapir A, Magzal F, Markman G, Tamir S
Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1

Eryanni S, Khatib S, Levi-Rosenzvig R, Tamir S, Szuchman-Sapir A
BBA Molecular and Cell Biology of Lipids 2015 Volume 1851 Pages 1118-1122

Gender effect on vascular responsiveness after bariatric surgery

A. Blum; S. Tamir; D. Hazzan; O. Podvitzky; R. Sirchan; L. Keinan-Boker; R. S. Ben-Shushan; N. Geron
Central European Journal of Medicine 2013 Volume 8 Issue 5 Pages 531-538

The Effect of ?In Favor of Myself?: Preventive Program to Enhance Positive Self and Body Image among Adolescents

Golan M, Hagay N, Tamir S.
PLoS ONE 2013 Volume 8 Issue 11

Gender effect on vascular inflammation following bariatric surgery

A. Blum; S. Tamir; D. Hazzan; O. Podvitzky; R. Sirchan; L. Keinan-Boker; R. S. Ben-Shushan; N. Blum; L. S. Suliman; N. Geron
European Cytokine Network 2012 Volume 23 Issue 4 Pages 154-157

Human atherosclerotic plaque lipid extract impairs the antioxidant defense capacity of monocytes

A. Szuchman-Sapir; M. Etzman; S. Tamir
Biochemical and Biophysical Research Communications 2012 Volume 423 Issue 4 Pages 884-888

Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin

H. Yehuda; Y. Soroka; M. Zlotkin-FruÅ¡iÄ?; A. Gilhar; Y. Milner; S. Tamir
Inflammation Research 2012 Volume 61 Issue 7 Pages 735-742

A decrease in VEGF and inflammatory markers is associated with diabetic proliferative retinopathy

A. Blum; D. Socea; R. S. Ben-Shushan; L. Keinan-Boker; M. Naftali; G. Segol; S. Tamir
European Cytokine Network 2012 Volume 23 Issue 4 Pages 158-162

Human atherosclerotic plaque lipid extract promotes expression of proinflammatory factors in human monocytes and macrophage-like cells

H. Yehuda; A. Szuchman-Sapir; S. Khatib; R. Musa; S. Tamir
Atherosclerosis 2011 Volume 218 Issue 2 Pages 339-343

Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts

D. Somjen; S. Katzburg; O. Sharon; G. H. Posner; N. Jaccard; D. Hendel; S. Tamir; J. Vaya
Journal of Steroid Biochemistry and Molecular Biology 2011 Volume 127 Issue 04-??? Pages 351-357

Endothelial dysfunction is reversible in helicobacter pylori-positive subjects

A. Blum; S. Tamir; K. Mualem; R. S. Ben-Shushan; L. Keinan-Boker; M. Paritsky
American Journal of Medicine 2011 Volume 124 Issue 12 Pages 1171-1174

Glabridin, a phytoestrogen from licorice root, up-regulates the intracellular antioxidant defense mechanism under glucose stress

Itamar Yehuda1, Zecharia Madar 2, Andrea Szuchman-Sapir1, Snait Tamir 1, 3.
Phytotherapy Research 2011 Volume 25 Issue 5 Pages 659-67

Potential skin antiinflammatory effects of 4-methylthiobutylisothiocyanate (MTBI) isolated from rocket (Eruca sativa) seeds

H. Yehuda; S. Khatib; I. Sussan; R. Musa; J. Vaya; S. Tamir
BioFactors 2009 Volume 35 Issue 3 Pages 295-305

The response of creatine kinase specific activity in rat pituitary to estrogenic compounds and vitamin d less-calcemic analogs

Dalia Somjen, Nitza Mirsky, Snait Tamir, Jacob Vaya, Gary H. Posner and Alvin M. Kaye
International Journal of Cell Biology 2009 Volume Article ID 273651 Pages 8 pages

Enhanced substituted resorcinol hydrophobicity augments tyrosinase inhibition potency

S. Khatib; O. Nerya; R. Musa; S. Tamir; T. Peter; J. Vaya
Journal of Medicinal Chemistry 2007 Volume 50 Issue 11 Pages 2676-2681

Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages

A. Szuchman; M. Aviram; K. Soliman; S. Tamir; J. Vaya
Free Radical Research 2006 Volume 40 Issue 1 Pages 41-52

Chalcones as potent tyrosinase inhibitors: The importance of a 2,4-substituted resorcinol moiety

S. Khatib; O. Nerya; R. Musa; M. Shmuel; S. Tamir; J. Vaya
Bioorganic and Medicinal Chemistry 2005 Volume 13 Issue 2 Pages 433-441

Estrogen-like activity of licorice root constituents: Glabridin and glabrene, in vascular tissues in vitro and in vivo

D. Somjen; E. Knoll; J. Vaya; N. Stern; S. Tamir
Journal of Steroid Biochemistry and Molecular Biology 2004 Volume 91 Issue 3 Pages 147-155

The relation between the chemical structure of flavonoids and their estrogen-like activities

J. Vaya; S. Tamir
Current Medicinal Chemistry 2004 Volume 11 Issue 10 Pages 1333-1343

Chalcones as potent tyrosinase inhibitors: The effect of hydroxyl positions and numbers

O. Nerya; R. Musa; S. Khatib; S. Tamir; J. Vaya
Phytochemistry 2004 Volume 65 Issue 10 Pages 1389-1395

Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues

D. Somjen; S. Katzburg; J. Vaya; A. M. Kaye; D. Hendel; G. H. Posner; S. Tamir
Journal of Steroid Biochemistry and Molecular Biology 2004 Volume 91 Issue 04-??? Pages 241-246