Sphingolipids, Natural-Bio Compounds and Immune Modulation Laboratory

Principal Researcher

054-9815556

dorita@migal.org.il

We strive to understand the mechanisms of inflammation and cancer that underlie the involvement of sphingolipids and to translate these laboratory discoveries into new therapies

Latest Publications

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans. FASEB J

Huang WC, Liang J, Nagahashi M, Avni D, Yamada A, Maceyka M, Wolen AR, Kordula T, Milstien S, Takabe K, Oravecz T, Spiegel S.

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Dr. Dorit Avni

2016

Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors. Immunol Lett

Katz S, Ernst O, Avni D, Athamna M, Philosoph A, Arana L, Ouro A, Hoeferlin LA, Meijler MM, Chalfant CE, Gómez-Muñoz

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Dr. Dorit Avni

2016

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer. Oncogenesis

NC Hait, D Avni, A Yamada, M Nagahashi, T Aoyagi, H Aoki, CI Dumur, Z Zelenko, EJ Gallagher, D Leroith, S Milstien, K Takabe and S Spiegel

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Dr. Dorit Avni

2015

Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol

Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S

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Dr. Dorit Avni

2015

Positions

Postdoctoral Marie Curie Fellowship Opportunities in Israel

2021-07-25

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