Red Blood Cell Research

Dr. Leonid Livshits

Title
Our research focuses on studying the physiological, biophysical, and rheological characteristics of healthy and pathological Red Blood Cells (RBCs), with a special emphasis on the RBC changes in metabolic complications and hemoglobinopathies.

 

The specific issues we work on include:

- Glucose uptake into human RBC: open (and very intriguing) questions.

Although the mechanisms of the regulation of glucose uptake and its impact on RBC physiology and rheology have been under intensive investigation for the last 70 years, we are still far from a complete understanding of these fundamental processes. The unique perturbations of numerous membrane protein complexes, the regulative redistribution of ATP, Ca 2+ , hemoglobin isoforms, and water molecules within the cell, the affected membrane charge, and adapted rheology are only a few from the myriads of the pathways triggered by acute glucose influx into human erythrocyte. 

The following questions are at the top of our research interest:

(a)   The regulative role of Protein Kinase C (PKC) isoforms in glucose transporter 1 (GLUT1)-mediated glucose transport.
(b)   The effect of insulin, adrenergic hormones, adipokines, and sex hormones on GLUT1-mediated uptake and associated processes in human RBC.
(c)   The influence of glucose uptake on RBC deformability: a possible regulative role of lipid raft constituents.
(d)   The mechanisms of altered glucose uptake in patients with congenital membranopathies and hemoglobinopathies in RBC.

- RBC Features as Early Prognostic Biomarkers

- The physiological and clinical roles of various hemoglobin isoforms with a particular view on the roles of minor adult hemoglobin, HbA2, and glycated hemoglobin.

Principal Researcher

Dr. Leonid Livshits

Dr. Leonid Livshits
Red Blood Cell Research
972-544931425

Our research focuses on studying the physiological, biophysical, and rheological characteristics of healthy and pathological Red Blood Cells (RBCs), with a special emphasis on the RBC changes in metabolic complications and hemoglobinopathies.&nbs

Latest Publications

Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening

Idit Lachover-Roth, Sari Peretz, Hiba Zoabi, Eitam Harel, Leonid Livshits, Dvora Filon, Carina Levin, Ariel Koren
2024

The effect of ionic redistributions on the microwave dielectric response of cytosol water upon glucose uptake

Cindy Galindo, Leonid Livshits, Lama Tarabeih, Yuri D Feldman
April 2024 European biophysics journal 53(17)
2024

Hemoglobin Binding to the Red Blood Cell (RBC) Membrane Is Associated with Decreased Cell Deformability

Gregory Barshtein, Leonid Livshits, Alexander Gural, Saul Yedgar
May 2024International Journal of Molecular Sciences 25(11):5814
2024

The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human Erythrocytes

Leonid Livshits, Sari Peretz, Anna Bogdanova,Max Gassmann
September 2023Cells
2023

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