Dr. Itai Sharon

Dr. Itai Sharon
Senior Lecturer (Assistant Professor)
Principal Investigator
Research Group Leader
Ph.D., 2010, Technion, Israel

Lab Website

Research Interests:

1. Plant-microbiome interactions

2. The diversity of the human-associated microbiome

3. Designing computational methods for metagenomics analysis

We are studying the microbiome of different environments. The lab utilizes molecular biology techniques along with advanced computational methods and data science approaches to generate and analyze metagenomics and other data. Currently, research in the lab is focused on human-associated microbes and plant-microbiome interactions.



Ph.D. Computer Science. Dissertation title: Computational methods for metagenomic analysis, Technion – Israel Institute of Technology.

M.Sc. Computer Science. Research focus: similarity detection for low complexity and remotely related proteins, Technion – Israel Institute of Technology.

B.Sc. Computer Science, Technion – Israel Institute of Technology.

Academic positions

2015 – present: Principal Investigator, MIGAL – Galilee Research Institute. Research focuses on the study of plant- and human-associated microbial communities.
2015 – present: Senior Lecturer, the Computer Science Department, Tel-Hai College. Teaches basic and advanced courses in programming, data science, and bioinformatics.
2010 – 2015: Postdoctoral Researcher, Department of Earth and Planetary Science, University of California, Berkeley. Research focus: dynamics and structure of microbial communities across different environments.

For a complete list of publications please check Dr. Sharon's Google scholar page

Scientific Publications

Mining marine metagenomes revealed a quorum-quenching lactonase with improved biochemical properties that inhibits the food spoilage bacteria Pseudomonas fluorescens

Haramati, R., Dor, S., Gurevich, D., Levy, D., Freund, D., Rytwo, G., Sharon, I., Afriat-Jurnou, L.

Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT

Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., Horn, M., Cohen, Y., Moor, A.E., Zeevi, D., Korem, T., Kotler, E., Harmelin, A., Itzkovitz, S., Maharshak, N., Shibolet, O., Pevsner-Fischer, M., Shapiro, H., Sharon, I., Halpern, Z., Segal, S. and Elinav, E.

Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features

Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., Cohen, Y., Linevsky, R., Rothschild, D., Moor, A.E., Ben-Moshe, S., Harmelin, A., Itzkovitz, S., Maharshak, N., Shibolet, O., Shapiro, H., Pevsner-Fischer, M., Sharon, I., Halpern, Z., Segal, E. and Elinav, E.

RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria.

Wrighton, K.C., Castelle, C.J., Varaljay, V.A., Satagopan, S., Brown, C.T., Wilkins, M.J., Thomas, B.C., Sharon, I., Williams, K.H., Tabita, F.R., Banfield, J.F.
ISME J. 2016

Critical biogeochemical functions in the subsurface are associated with bacteria from new phyla and little studied lineages.

Hug, L.A., Thomas, B.C., Sharon, I., Brown, C.T., Sharma, R., Hettich, R.L., Wilkins, M.J., Williams, K.H., Singh, A., Banfield, J.F.
Environ Microbiol. 2016 Volume 18 Issue 1 Pages 159-173

Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system

Anantharaman, K., Brown, C.T., Hug, L.A., Sharon, I., Castelle, C.J., Probst, A.J., Thomas, B.C., Singh, A., Wilkins, M.J., Karaoz, U., Brodie, E.L., Williams, K.H., Hubbard, S.S., Banfield, J.F.
Nat Commun 2016 Issue 13219 (2016)

Evidence for persistent and shared bacterial strains against a background of largely unique gut colonization in hospitalized premature infants.

Raveh-Sadka, T., Firek, B., Sharon, I., Baker, R., Brown, C.T., Thomas, B.C., Morowitz, M.J., Banfield, J.F.
ISME J. 2016

Genomic resolution of a cold subsurface aquifer community provides metabolic insights for novel microbes adapted to high CO2 concentrations.

Probst, A.J., Castelle, C.J., Singh, A., Brown, C.T., Anantharaman, K., Sharon, I., Hug, L.A., Burstein, D., Emerson, J.B., Thomas, B.C., Banfield, J.F.
Eviron Microbiol. 2016

Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems.

Burstein, D., Sun, C.L., Brown, C.T., Sharon, I., Anantharaman, K., Probst, A.J., Thomas, B.C., Banfield, J.F.
Nat Commun, 2016

Critical biogeochemical functions in the subsurface are associated with bacteria from new phyla and little studied lineages

Hug, L.A., Thomas, B.C., Sharon, I., Brown, C.T., Sharma, R., Hettich, R.L., Wilkins, M.J., Williams, K.H., Singh, A., Banfield, J.F.
Environ Microbiol 2015

Gut bacteria are rarely shared by cohospitalized premature infants, regardless of necrotizing enterocolitis development

Raveh-Sadka, T., Thomas, B.C., Singh, A., Firek, B., Brooks, B., Castelle, C.J., Sharon, I., Baker, R., Good, M., Morowitz, M.J., Banfield, J.F.
eLife 2015 Volume 4 Pages e05477

Unusual biology across a group comprising more than 15% of domain Bacteria

Brown, C.T., Hug, L.A., Thomas, B.C., Sharon, I., Castelle, C.J., Singh, A., Wilkins, M.J., Wrighton, K.C., Williams, K.H. and Banfield, J.F.
Nature 2015

Accurate, multi-kb reads resolve complex populations and detect rare microorganisms

Sharon, I., Kertesz, M., Hug, L.A., Pushkarev, D., Blauwkamp, T.A., Castelle, C.J., Amirebrahimi, M., Thomas, B.C., Burstein, D., Tringe, S.G., Williams, K.H., Banfield, J.F.
Genome Res 2015 Volume 25 Pages 534-543

CRISPR immunity drives rapid phage genome evolution.

Paez-Espino, D., Sharon, I., Morovic, W., Stahl, B., Thomas, B.C., Barrangou, R., Banfield, J.F.
mBio 2015 Volume 6 Issue 2 Pages e00262-15

Metabolic interdependencies between phylogenetically novel fermenters and respiratory organisms in an unconfined aquifer

Wrighton, K.C., Castelle, C.J., Wilkins, M.J., Hug, L.A., Sharon, I., Thomas, B.C., Handley, K.M., Mullin, S.W., Nicora, C.D., Singh, A., Lipton, M.S., Long, P.E., Williams, K.H., Banfield, J.F.
ISME J 2014 Volume 8 Issue 7 Pages 1452-1463

Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants

Brooks, B., Firek, B.A., Miller, C.S., Sharon, I., Thomas, B.C., Baker, R., Morowitz, M.J., Banfield, J.F.
Microbiome 2014 Volume 2 Issue 1

Community genomic analyses constrain the distribution of metabolic traits across the Chloroflexi phylum and indicate roles in sediment carbon cycling

Hug, L.A., Castelle, C.J., Wrighton, K.C., Thomas, B.C., Sharon, I., Frischkorn, K.R., Williams, K.H., Tringe, S.G., Banfield, J.F
Microbiome 2013 Volume 1 Issue 22

Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization

Sharon, I., Morowitz, M.J., Thomas, B.C., Costello, E.K., Relman, D.A., Banfield, J.F
Genome Res 2013 Volume 23 Issue 1 Pages 111-120

Genome resolved analysis of a premature infant gut microbial community reveals a Varibaculum cambriense genome and a shift towards fermentation-based metabolism during the third week of life

Brown, C.T., Sharon, I., Thomas, B.C., Castelle, C.J., Morowitz, M.J., Banfield, J.F.
Microbiome 2013 Volume 1 Issue 30

Perspective: Genomes from metagenomics

Sharon, I., Banfield, J.F.
Science 2013 Volume 342 Issue 6162 Pages 1057-1058

Small genomes and sparse metabolisms of sediment-associated bacteria from four candidate phyla

Kantor, R.S., Wrighton, K.C., Handley, K.M., Sharon, I., Hug, L.A., Castelle, C.J., Thomas, B.C., Banfield, J.F
mBio 2013 Volume 4 Issue 5 Pages e00708-13

The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria

Di Rienzi, S.C.*, Sharon, I.*, Wrighton, K.C., Koren, O., Hug, L.A., Thomas, B.C., Goodrich, J.K., Bell, J.T., Spector, T.D., Banfield, J.F., Ley, R.E.
eLife 2013 Volume 2 Pages e01102

Biostimulation induces syntrophic interactions that impact C, S and N cycling in a sediment microbial community

Handley, K.M., VerBerkmoes, N.C., Steefel, C.I., Williams, K.H., Sharon, I., Miller, C.S., Frischkorn, K.R., Chourey, K., Thomas, B.C., Shah, M.B., Long, P.E., Hettich, R.L., Banfield, J.F
ISME J 2012 Volume 7 Issue 4 Pages 800-816

Fermentation, Hydrogen and Sulfur Metabolism in Multiple Uncultivated Bacterial Phyla

Wrighton, K.C., Thomas, B.C., Sharon, I., Miller, C.S., Castelle, C.J., VerBerkmoes, N.C., Wilkins, M.J., Hettich, R.J., Lipton, M.S., Williams, K.H., Long, P.E., Banfield, J.F
Science 2012 Volume 337 Issue 6102 Pages 1661-1665

Genomic island variability facilitates Prochlorococcus-virus coexistence

Avrani, S., Wurtzel, O., Sharon, I., Sorek, R., Lindell, D
Nature 2011 Volume 474 Pages 604-608