Dr. Ruth Cohen-Khait

Ruth Cohen-Khait
Principal Investigator
Dr. Ruth Cohen-Khait
Assistant Professor
Research Group Leader
Research Group Leader
PhD
Shaping bacterial communities applying bacteriocins and directed evolution

My research interests are to develop a way to mimic natural processes of bacterial community shaping. Bacterial communities are constantly shaped and rearranged by proteins and nucleic acids which are released by different members of the bacterial community. I would like to develop a method which would allow to alter bacterial communities in a similar manner, applying laboratory designed bacteriocin derivatives. The ability to insert/eliminate specific bacterial strains and species in a rational manner, while maintaining the overall bacterial community may lead to therapeutic, agricultural, environmental, and industrial breakthroughs as bacterial communities are everywhere, and often issue a significant impact on their surroundings.   

CV

BSc (cum laud) - The Hebrew university of Jerusalem

Subject

Years

Psychobiology - a combined program in psychology and biology.

2004-2007

MSc (cum laud) - The Hebrew university and the interuniversity institute for marine sciences in Eilat

Subject

Years

Nutritional ecology of herbivorous fish

Advisor: Prof Amatzia Genin

2007-2009

PhD - The Weizmann institute of science

Subject

Years

Biochemistry and evolution of protein-protein interactions
Advisor: Prof Gideon Schreiber

2010-2017
(Same topic as a postdoc May-Dec 2017)

Postdoc - Oxford University

Subject

Years

Specialized 3D folds determine translocation processes of protein antibiotics
Advisor: Prof Colin Kleanthous

2018 – 2021

 

Scientific Publications

Imaging bacterial membrane vesicles with a delicate touch

Ruth Cohen-Khait
Nature Reviews Microbiology
2021

Colicin-mediated transport of DNA through the iron transporter FepA

Ruth Cohen-Khait, Ameya Harmalkar, Phuong Pham, Melissa N Webby, Nicholas G Housden, Emma Elliston, Jonathan TS Hopper, Shabaz Mohammed, Carol V Robinson, Jeffrey J Gray, Colin Kleanthous
mBio
2021

Selecting for fast protein–protein association as demonstrated on a random TEM1 yeast library binding BLIP

Ruth Cohen-Khait, Gideon Schreiber
Biochemistry
2018

Promiscuous protein binding as a function of protein stability

Ruth Cohen-Khait, Orly Dym, Shelly Hamer-Rogotner, Gideon Schreiber
Structure
2017

Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders

Ruth Cohen-Khait, Gideon Schreiber
PNAS
2016

Food selectivity and diet switch can explain the slow feeding of herbivorous coral-reef fishes during the morning

Ruth Khait, Uri Obolski, Lilach Hadany, Amatzia Genin
PLoS One
2013

FRETex: a FRET-based, high-throughput technique to analyze protein–protein interactions

Ruth Khait, Gideon Schreiber
PEDS
2012

Contrasting factors on the kinetic path to protein complex formation diminish the effects of crowding agents

Yael Phillip, Michal Harel, Ruth Khait, Sanbo Qin, Huan-Xiang Zhou, Gideon Schreiber
Biophysical Journal
2012