A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation
Curr Opin Genet Dev. 2024 Aug;87:102235
XIST directly regulates X-linked and autosomal genes in naïve human pluripotent cells
Dror I, Chitiashvili T, Tan S, Cano C, Sahakyan A, Markaki Y, Chronis C, Collier A, Deng W, Liang G, Sun Y, Afasizheva A, Miller J, Xiao W, Black D, Ding F, Plath K
Cell. 2024 Jan 4;187(1):110-129.e31
Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode
Elkoshi N, Parikh S, Malcov-Brog H, Parikh R, Manich P, Netti F, Maliah A, Elkoshi H, Haj M, Rippin I, Frand J, Perluk T, Haiat-Factor R, Golan T, Regev-Rudzki N, Kiper E, Brenner R, Gonen P, Dror I, Levi H, Hameiri O, Cohen-Gulkar M, Eldar-Finkelman H, Ast G, Nizri E, Ziv Y, Elkon R, Khaled M, Ebenstein Y, Shiloh Y, Levy C.
J Invest Dermatol. 2023 Dec;143(12):2494-2506.e4.
FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes
Chitiashvili T, Hsu FM, Dror I, Plath K, Clark A.
Stem Cell Reports. 2022 Jun 14;17(6):1268-1278
Xist nucleates local protein gradients to propagate silencing across the X chromosome
Markaki Y, Chong JG, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schӧneberg J, Heard E, Guttman M, Chou T, Plath K.
Cell. 2021 Dec 9;184(25):6212
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
Chitiashvili T, Dror I, Kim R, Hsu FM, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke-Layland K, Plath K, Clark A.
Nat Cell Biol. 2020 Dec;22(12):1436-1446
UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems
Malcov-Brog H, Alpert A, Golan T, Parikh S, Nordlinger A, Netti F, Sheinboim D, Dror I, Thomas L, Cosson C, Gonen P, Stanevsky Y, Brenner R, Perluk T, Frand J, Elgavish S, Nevo Y, Rahat D, Tabach Y, Khaled M, Shen-Orr SS, Levy C.
Mol Cell. 2018 Nov 1;72(3):444-456.e7
OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
Sheinboim D, Maza I, Dror I, Parikh S, Krupalnik V, Bell RE, Zviran A, Suita Y, Hakim O, Mandel-Gutfreund Y, Khaled M.
Nature Communications. 2017 Oct 18;8(1):1022
Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
Schöne S, Jurk M, Helabad MB, Dror I, Lebars I, Kieffer B, Imhof P, Rohs R, Vingron M, Thomas-Chollier M, Meijsing SH.
Nature communications. 2016 Sep 1;7:12621
How motif environment influences transcription factor search dynamics: Finding a needle in a haystack
Dror I, Rohs R, Mandel‐Gutfreund Y.
BioEssays. 2016 Jul 1;38(7):605-12
A widespread role of the motif environment in transcription factor binding across diverse protein families
Dror I, Golan T, Levy C, Rohs R, Mandel-Gutfreund Y.
Genome research. 2015 Sep 1;25(9):1268-80. (Selected for top ten paper awards in RECOMB conference 2016)
Deconvolving the recognition of DNA shape from sequence
Abe N, Dror I, Yang L, Slattery M, Zhou T, Bussemaker HJ, Rohs R, Mann RS.
Cell. 2015 Apr 9;161(2):307-18. (Selected for top ten paper awards in RECOMB conference 2015)
TFBSshape: a motif database for DNA shape features of transcription factor binding sites
Yang L, Zhou T, Dror I, Mathelier A, Wasserman WW, Gordân R, Rohs R.
Nucleic acids research. 2013 Nov 7;42(D1):D148-55. (Selected as Nucleic Acid Research breakthrough article)
Covariation between homeodomain transcription factors and the shape of their DNA binding sites
Dror I, Zhou T, Mandel-Gutfreund Y, Rohs R.
Nucleic acids research. 2013 Sep 27;42(1):430-41. (Selected as the Faculty of Biology, Technion, paper of the month)
DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale
Zhou T, Yang L, Lu Y, Dror I, Dantas Machado AC, Ghane T, Di Felice R, Rohs R.
Nucleic acids research. 2013 May 22;41(W1):W56-62
Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape
Gordân R, Shen N, Dror I, Zhou T, Horton J, Rohs R, Bulyk ML.
Cell reports. 2013 Apr 25;3(4):1093-104. (Selected for top ten paper awards in RECOMB 2013)
Proteopedia: 3D visualization and annotation of transcription factor–DNA readout modes
Machado AC, Saleebyan SB, Holmes BT, Karelina M, Tam J, Kim SY, Kim KH, Dror I, Hodis E, Martz E, Compeau PA
Biochemistry and Molecular Biology Education. 2012 Nov 1;40(6):400-1
Predicting nucleic acid binding interfaces from structural models of proteins
Dror I, Shazman S, Mukherjee S, Zhang Y, Glaser F, Mandel‐Gutfreund Y
Proteins: Structure, Function, and Bioinformatics. 2012 Feb 1;80(2):482-9
Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS
Cell. 2011 Dec 9;147(6):1270-82. (Selected for top ten paper awards in RECOMB conference 2011)
SFmap: a web server for motif analysis and prediction of splicing factor binding sites
Paz I, Akerman M, Dror I, Kosti I, Mandel-Gutfreund Y.
Nucleic acids research. 2010 May 25;38(suppl_2):W281-5
