Dr. Or Shahar

Dr. Or Shahar
Principal Investigator
Or Shahar
Research Group Leader

Lab Website

Full CV (PDF)
Research Interests:

Molecular dynamics in the brain, control of mRNA translation, molecular mechanisms of memory formation, brain development, newly synthesized proteins during aging, genomic stability and neurodegenerative diseases, cultured fish meat.



PhD 2013, Genetics, The Hebrew University of Jerusalem.

MsC 2007, Genetics, The Hebrew University of Jerusalem.

Academic and Research Experience

2021- Head of Molecular Neurodynamics Laboratory, MIGAL.

2020 Postdoctoral researcher, Tel Aviv University. 

2019- Initiative for high-throughput production of antibodies in collaboration with Ramot and the Bar Lab of Tel Aviv University.

2013-2019 EMBO and Marie Curie Postdoctoral fellow. Max Planck Institute for Brain Research, Germany.


Scientific Publications

Editorial: Molecular Links Between Metabolism and Neural Dysfunction

A Meerson, O Shahar, I Mor
Frontiers in Neuroscience 17, 963

Learning and memory formation in zebrafish: Protein dynamics and molecular tools

Kitty Reemst, Heba Shahin and Or D Shahar

Large-scale cell-type-specific imaging of protein synthesis in a vertebrate brain.

Shahar OD, Schuman EM.

Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge

Kasper Langebeck-Jensen, Or D Shahar, Erin M Schuman, Julian D Langer, Soojin Ryu

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

Shahar OD, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, Mazina O, Bramson S, Kupiec M, Eden A, Meshorer E, Mazin AV, Brino L, Goldberg M, Soutoglou E.

Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro

Or David Shahar, Ronen Gabizon, Oren Feine, Raphael Alhadeff, Assaf Ganoth, Liron Argaman, Elee Shimshoni, Assaf Friedler, Michal Goldberg
PLoS One

APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair

Nowarski R, Wilner OI, Cheshin O, Shahar OD, Kenig E, Baraz L, Britan-Rosich E, Nagler A, Harris RS, Goldberg M, Willner I, Kotler M

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

C Lemaître, B Fischer, A Kalousi, A-S Hoffbeck, J Guirouilh-Barbat, O D Shahar, D Genet, M Goldberg, P Betrand, B Lopez, L Brino, E Soutoglou

Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cell

O D Shahar1, E V S Raghu Ram, E Shimshoni, S Hareli, E Meshorer, M Goldberg

Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties

Sklan EH, Berson A, Birikh KR, Gutnick A, Shahar O, Shoham S, Soreq H.
Biol Psychiatry