The Shahar Lab - Molecular Neurodynamics

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We study molecular dynamics in the brain and mechanisms of mRNA translation control.

Our interests include:

  1. To elucidate molecular mechanisms of memory formation.
  2. To define molecular pathways of brain development in health and disease.
  3. To better understand the mechanisms leading to neurodegeneration, focusing on genomic-instability-related disorders.
  4. To reveal molecular networks affecting aging.

Our model systems include cell cultures and zebrafish which are well suited for our aims.

We use state of the art microscopy, cell-type-specific proteomics and sequencing combined with computational analysis.

Check out our recent publication in which we developed a transgenic zebrafish line allowing for the labeling of newly-synthesized-proteins in a cell-type-specific manner in neurons.

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Join us for exciting, fun science!

We are looking for enthusiastic graduate students, a lab technician and postdocs. If you are interested, please email Or Shahar.

Principal Researcher

Lab News

Outreach activity

Or Shahar gave a volunteer lecture at Unistream, a non profit organization exposing young students from the periphery to science and innovation.

Unistream seminar1

In the Media

Title
Migal Institute for Peripheral Youth with Love

Dr. Shahar teaching high schoolers
Read More  in Hebrew

Latest Publications

Large-scale cell-type-specific imaging of protein synthesis in a vertebrate brain.

Shahar OD, Schuman EM.
Elife
2020

Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge

Kasper Langebeck-Jensen, Or D Shahar, Erin M Schuman, Julian D Langer, Soojin Ryu
Proteomics
2019

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

Shahar OD, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, Mazina O, Bramson S, Kupiec M, Eden A, Meshorer E, Mazin AV, Brino L, Goldberg M, Soutoglou E.
2014