Vascular Signaling Research

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).

Dr. Andrea Szuchman-Sapir

Title
Overview

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome P450-derived lipid mediators in vascular homeostasis and dilation that affects blood pressure. In addition, the role of paraoxonase 1 in the endothelium signaling cascades that affect endothelium-dependent relaxation is been investigated. 

Principle Researcher

Latest Publications

The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells

Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
Free Radical Biology and Medicine
2020

Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.

Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A.
2018

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.

Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
FRBM 2017 Volume 103 Pages 87?94
2017

In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.

Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
PLoS One 2017 Volume 24 Issue 5 Pages 1-14
2017