Vascular Signaling Research

The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).

Dr. Andrea Szuchman-Sapir

Latest Publications

The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells

Ben-David Raz, Chuyun Dimitry, Szuchman-Sapir Andrea
Free Radical Biology and Medicine

Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.

Gilad D, Atiya S, Mozes-Autmazgin Z, Shelly Ben-Shushan R, Ben-David R, Amram E, Tamir S, Chuyun D, and Szuchman-Sapir A.

In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.

Magzal F, Sela S, Szuchman-Sapir A, Tamir S, Michelis R, Kristal B
PLoS One 2017 Volume 24 Issue 5 Pages 1-14

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.

Levi-Rosenzvig R, Beyer AB, Hockenberry J, Shelly Ben-Shushan R, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A.
FRBM 2017 Volume 103 Pages 87?94

Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation

Yehuda I, Madar Z, Leikin-Frenkel A, Szuchman-Sapir A, Magzal F, Markman G, Tamir S
Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99