The research in our laboratory focuses on the elucidation of signal transduction mechanisms in the vessel wall, in particular in the endothelium, and on the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs).
The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells
Free Radical Biology and Medicine
Paraoxonase 1 in endothelial cells impairs vasodilation induced by arachidonic acid lactone metabolite.
In-vivo oxidized albumin? a pro-inflammatory agent in hypoalbuminemia.
PLoS One 2017 Volume 24 Issue 5 Pages 1-14
5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation.
FRBM 2017 Volume 103 Pages 87?94
Glabridin, an isoflavan from licorice root, up-regulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation
Molecular Nutrition & Food Research 2016 Volume 60 Issue 2 Pages 287-99