Directed Evolution of Enzymes
Enzymes are extremely potent biocatalysts capable of enhancing reaction rates by up to 1019-fold (kcat/knoncat). Despite their great proficiency, enzymes exhibit a remarkable evolutionary adaptability (evolvability).
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering
New homologues of Brassicaceae water?soluble chlorophyll proteins shed light on chlorophyll binding, spectral tuning and molecular evolution.
Febs Journal 2019 Pages febs.15068
"Directed evolution of an endoinulinase from Talaromyces purpureogenus toward efficient production of inulooligosaccharides"
The role of protein dynamics in the evolution of new enzyme function
Nature Chemical Biology 2016