Directed Evolution of Enzymes

Dr. Livnat Afriat-Jurnou

Principal Researcher

Dr. Livnat Afriat-Jurnou

Dr. Livnat Afriat-Jurnou
Directed Evolution of Enzymes
972-4-7700403
972-556669613

Enzymes are extremely potent biocatalysts capable of enhancing reaction rates by up to 1019-fold (kcat/knoncat).  Despite their great proficiency, enzymes exhibit a remarkable evolutionary adaptability (evolvability).

Latest Publications

Mining marine metagenomes revealed a quorum-quenching lactonase with improved biochemical properties that inhibits the food spoilage bacteria Pseudomonas fluorescens

Haramati, R., Dor, S., Gurevich, D., Levy, D., Freund, D., Rytwo, G., Sharon, I., Afriat-Jurnou, L.
2021

Bacterial Quorum-Quenching Lactonase Hydrolyzes Fungal Mycotoxin and Reduces Pathogenicity of Penicillium expansum-Suggesting a Mechanism of Bacterial Antagonism

Shlomit Dor , Dov Prusky, Livnat Afriat-Jurnou
Journal of Fungi
2021

Identification and Characterization of a New Quorum-Quenching N-acyl Homoserine Lactonase in the Plant Pathogen Erwinia amylovora

Sapir Yaar Bar, Shlomit Dor, Mayan Erov, Livnat Afriat-Jurnou
Journal of Agricultural and Food Chemistry
10.1021/acs.jafc.1c00366
2021

Directed Enzyme Evolution and Encapsulation in Peptide Nanospheres of Quorum Quenching Lactonase as an Antibacterial Treatment against Plant Pathogen

David Gurevich , Shlomit Dor , Mayan Erov , Yoav Dan , Jehudith Clara Moy , Orly Mairesse , Mery Dafny-Yelin , Lihi Adler-Abramovich , Livnat Afriat-Jurnou
ACS Appl. Mater. Interfaces
2021