We are interested in understanding the molecular mechanisms that govern the evolution of new functions in microbial enzymes concerning their biological role and applying scientific insights to solve fundamental and applicative problems using protein engineering.
Principal Researcher
Dr. Livnat Afriat-Jurnou
Enzymes Evolution and Environmental and Applied Microbiology
972-4-7700403
972-556669613
Team
Former Group Members
Former Group Members
Dr. Ofir Gershoni
Rami Harmati
Sapir Yaar-bar
Keren Nudel
David Gurevich
Guy Or
Mayan Erov
Maria Vetcos
Collaborations
Collaborations
Funding
Patents
Yadid I, Cohen R, Afriat-Jurnou L, "Improved endoinulinase", MIGAL APPLIED RESEARCH, LTD, PCT/IL2018/050872, 07 Aug 2018.
Afriat-Jurnou L, Erov M, Gurevich D, and Mery Dafny-Yalin. "Stabilized mutants of quorum quenching lactonase as antibacterial treatment for plant pathogens". MIGAL APPLIED RESEARCH, LTD, PCT/IL2020/050673, 17-Jun-2020.
Adler-Abramovich L., Afriat-Jurnou L. “Peptide nanospheres and nanotubes encapsulating quorum quenching lactonase and uses". MIGAL APPLIED RESEARCH US Patent Application No. 63/040,299.
Afriat-Jurnou L., Dov Prusky, "USE OF STABILIZED MUTANTS OF LACTONASE IN TREATMENT OF FUNGI". MIGAL APPLIED RESEARCH. U.S. Patent Application Number 63/126,277, filed December 16, 2020.
Afriat-Jurnou L. Itai Sharon. QUORUM QUENCHING ENZYME, AND METHODS OF USING SAME “,PCT Patent Application No. PCT/IL2022/050792.
Latest Publications
Mining marine metagenomes revealed a quorum-quenching lactonase with improved biochemical properties that inhibits the food spoilage bacteria Pseudomonas fluorescens
2021
Bacterial Quorum-Quenching Lactonase Hydrolyzes Fungal Mycotoxin and Reduces Pathogenicity of Penicillium expansum-Suggesting a Mechanism of Bacterial Antagonism
Journal of Fungi
2021
Identification and Characterization of a New Quorum-Quenching N-acyl Homoserine Lactonase in the Plant Pathogen Erwinia amylovora
Journal of Agricultural and Food Chemistry
10.1021/acs.jafc.1c00366
10.1021/acs.jafc.1c00366
2021
Directed Enzyme Evolution and Encapsulation in Peptide Nanospheres of Quorum Quenching Lactonase as an Antibacterial Treatment against Plant Pathogen
ACS Appl. Mater. Interfaces
2021
Lab News
Congaratulations to our graduats!
Congratulations to all of our MSC graduates, who received their degrees this week-Rami, Keren and Guy. Also congratulations to Dor and Ariel, Master students in the lab who received their BSc.