Natural Products and Analytical Chemistry

Prof. Soliman Khatib

Genome-wide localization of the polyphenol quercetin in human monocytes.

Atrahimovich1 D., Samson A. O., Barsheshet Y., Vaya J., Khatib S. and Reuveni A.

Lyso‐diacylglyceryltrimethylhomoserine (lyso‐DGTS) isolated from Nannochloropsis microalgae improves high‐density lipoprotein (HDL) functions.

Khattib A., Atrahimovich D., Dahli L., Vaya J., and Khatib S.

Ovine plasma dipalmitoylphosphatidylcholine does not predict decompression bubbling.

Arieli R., Khatib S., and Vaya J.
Respiratory Physiology & Neurobiology 2019 Volume 259 Pages 26-29

Lyso-DGTS lipid isolated from microalgae enhances PON1 activities in vitro and in vivo, increases PON1 penetration into macrophages and decreases cellular lipid accumulation.

Dahli L., Atrahimovich D., Vaya J. and Khatib S.
BioFactors 2018 Volume 44 Issue 3 Pages 299-310

Nannochloropsis sp. ethanol extract prevents macrophage and LDL oxidation and enhances PON1 activity through the principal active compound lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS)

Khatib S., Artoul F., Paluy I., Boluchevsky L., Kvitnitsky E., Vaya J.
Journal of Applied Phycology 2018 Volume 30 Issue 3 Pages 1679-1689

Punicalagin decreases serum glucose levels and increases PON1 activity and HDL anti-inflammatory values in Balb/c mice fed a high-fat diet

Atrahimovich D., Samson A. O., Khattib A., Vaya, J. and Khatib S.
Oxidative Medicine and Cellular Longevity 2018 Volume 2018 Issue 5 Pages 1-8

High-Density Lipoproteins (HDL) Composition and Function in Preeclampsia.

Einbinder Y., Biron-Shemtal T., Agassi-Zaitler M., Tzadikevich-Geffen K., Vaya J., Khatib S., Ohana M., Benchetrit S., and Zitman-Gal T.
Archives of Gynecology and Obstetrics 2018 Volume 298 Issue 2 Pages 405-413

Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human ??Synuclein: Comparison with Dopaminergic and Serotonergic Denervation

Finberg, J. Aluf, Y. Loboda, Y. Nakhleh, M. K Jeries, R. Aboud M. Zubedat,S. Avital,A. Khatib, K. Vaya, J. and Haick H.
ACS chemical neuroscience 2017

Human carotid atherosclerotic plaque protein(s) change HDL protein(s) composition and impair HDL anti-oxidant activity.

Cohen, E., Aviram, M., Khatib, S., Volkova, N., Vaya, J.
BioFactors 2016 Volume 42 Pages 115-128

Punicalagin induces serum low-density lipoprotein (LDL) influx to macrophages

Atrahimovich D., Khatib S., Vaya J., Sela S. and Samson A. O.
Oxidative Medicine and Cellular Longevity 2016 Volume 2016, Article number 7124251 Pages 9 p.

Dipalmitoyl-phosphatidyl-choline from the lungs at the vascular active hydrophobic spots, which bubble on decompression

Arieli R., Khatib S. and Vaya J.
Journal of Applied Physiology 2016 Volume 121 Pages 811-815

5,6-?-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1

Eryanni S, Khatib S, Levi-Rosenzvig R, Tamir S, Szuchman-Sapir A
BBA Molecular and Cell Biology of Lipids 2015 Volume 1851 Pages 1118-1122

Human carotid atherosclerotic lesion protein components decrease cholesterol biosynthesis rate in macrophages through 3-hydroxy-3-methylglutaryl-CoA reductase regulation

Elad Cohen., Michael Aviram., Soliman Khatib., Mira Rosenblat., Jacob Vaya
BioFactors 2015 Volume 41 Issue 1 Pages 28-34

Analysis of volatile organic compounds in rats with dopaminergic lesion: possible application for early detection of Parkinson?s disease

S. Khatib, J.P.M. Finberg, F. Artoul, Y. Lavner, S. Mahmood, U. Tisch, H. Haick, Y. Aluf, J. Vaya
Neurochemistry International 2014 Volume 76 Pages 82-90

The effect of haptens on protein-carrier immunogenicity

Gefen, T., Vaya, J., Khatib, S., Rapoport, I., Lupo, M., Dan Heller, E., Aizenshtein, E., & Pitcovski, J.
Immunology 2014 Volume 144 Pages 116-126

Human carotid plaque Phosphatidyl Choline (PC), specifically interacts with Paraoxonase1 (PON1), increases its activity and enhances its uptake by macrophage at the expense of its binding to HDL

Elad Cohen, Michael Aviram, Soliman Khatib, Fadi Artul, Asaf Rabin, Dalit Mannheim, Ron Karmeli, Tal Salamon and Jacob Vaya
Free Radical Biology and Medicine 2014 Volume 76 Pages 14-24

The synthesis and analysis of S-nitorsylated paraoxonase 1

Khatib S, Artoul F, Gershko M, Markman G, Vaya J.
Biochem Biophys Res Commun 2014 Volume 444 Pages 354-359

Neural HO-1/sterol interactions in vivo: Implications for Alzheimer's disease

Hascalovici JR, Song W, Liberman A, Vaya J, Khatib S, Holcroft C, Laferla F, Schipper HM
Neuroscience 2014 Volume 280 Pages 40-49

Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque

S. Khatib; J. Vaya
Biochemical and Biophysical Research Communications 2014

Reduced glutathione (GSH) increases quercetin stimulatory effects on HDL- or apoA1- mediated cholesterol efflux from J774A.1 macrophages

Rosenblat M, Volkova N, Khatib S, Mahmood S, Vaya J, Aviram M.
Free Radic Res 2014 Volume 48 Issue 12 Pages 1462-1472

The impact of PEGylation on protein immunogenicity

T. Gefen; J. Vaya; S. Khatib; N. Harkevich; F. Artoul; E. D. Heller; J. Pitcovski; E. Aizenshtein
International Immunopharmacology 2013 Volume 15 Issue 2 Pages 254-259

Selective inhibition of monoamine oxidase A or B reduces striatal oxidative stress in rats with partial depletion of the nigro-striatal dopaminergic pathway

Y. Aluf; J. Vaya; S. Khatib; Y. Loboda; J. P. M. Finberg
Neuropharmacology 2013 Volume 65 Pages 48-57

The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study

D. Atrahimovich; J. Vaya; S. Khatib
Bioorganic and Medicinal Chemistry 2013 Volume 21 Issue 11 Pages 3348-3355

Glabridin protects paraoxonase 1 from linoleic acid hydroperoxide inhibition via specific interaction: A fluorescence-quenching study

D. Atrahimovich; J. Vaya; H. Tavori; S. Khatib
Journal of Agricultural and Food Chemistry 2012 Volume 60 Issue 14 Pages 3679-3685

Increased levels of human carotid lesion linoleic acid hydroperoxide in symptomatic and asymptomatic patients, is inversely correlated with serum HDL and paraoxonase 1 activity.

E. Cohen, M. Aviram, S. Khatib, A. Rabin, D. Mannheim, R. Karmeli, J. Vaya.
Journal of Lipids 2012 Volume 2012 Pages Article ID 762560